26625-17-2Relevant academic research and scientific papers
Computational and DNMR Analysis of the Conformational Isomers and Stereodynamics of Secondary 2,2′-Bisanilides
Mazzanti, Andrea,Chiarucci, Michel,Prati, Luca,Bentley, Keith W.,Wolf, Christian
, p. 89 - 99 (2016)
The conformational preference of 2,2′-bisanilides was investigated by variable-temperature NMR spectroscopy, NMR titration and diffusion experiments, IR spectroscopy, computational analysis, and X-ray crystallography. The formation of a conformation havin
A modified Cu(0)-Cu(I)-mediated Caryl-CarylUllmann coupling for the synthesis of biaryls
Yasamut, Kittisak,Jongcharoenkamol, Jira,Ruchirawat, Somsak,Ploypradith, Poonsakdi
, p. 5994 - 6000 (2016/09/14)
A novel Cu(0)-Cu(I)-mediated Caryl-CarylUllmann coupling has been successfully developed. The use of Cu(I) salts allowed the reactions to proceed under relatively mild conditions (65?°C in DMSO for 15–72?h). The developed method was compatible with a relatively wide range of functional groups simultaneously present on the aromatic ring of different electronic nature. The aryl halides with an electron-withdrawing group ortho to the halide or an electron-donating group meta or para to the halide furnished the corresponding products in good to excellent yields (up to 98%).
PALLADIUM-CATALYSED CYCLISATION OF 2-SUBSTITUTED HALOGENOARENES BY DEHYDROHALOGENATION
Ames, D.E.,Opalko, A.
, p. 1919 - 1926 (2007/10/02)
Cyclodehydrohalogenation mediated by various palladium catalysts and solvents with different bases (the most generally satisfactory system being palladium(II) acetate in NN-dimethylacetamide (DMA) with sodium carbonate as base) has been examined as a route to some heterocyclic systems.Whereas dehydrogenative cyclisation processes require stoichiometric amounts of palladium(II) reagent, the present procedure involves only catalytic amounts (0.1 molar proportion, or less), of palladium compound.The preparation of dibenzofuran, carbazole, fluorenone, 6H-dibenzothiazine-5,5-dioxide, 6H-dibenzopyran and benzofuranopyridine derivatives is described.The cyclisation of 3-benzamido-2-chloropyridine to 6-hydroxybenzonaphthiridine illustrates the regiospecificity of the process.
