266352-95-8

Upstream product

• 266352-93-6 1-benzyloxymethyl-3,5-dimethoxy-1,4-dihydrobenzene 
• 70150-67-3 5-(benzyloxymethyl)cyclohexane-1,3-dione 
• 100-39-0 benzyl bromide 
• 90612-16-1 (3,5-dimethoxycyclohexa-2,5-dien-1-yl)methanol 
• 615-43-0 2-iodophenylamine 
• 266352-94-7 5-benzyloxymethyl-3-(2-iodophenyl)amino-2-cyclohexen-1-one 

Downstream Products

• 221299-79-2 2-(p-toluenesulfonyl)oxymethyl-1,2,3,9-tetrahydro-4H-carbazol-4-one 

Relevant academic research and scientific papers

Butyrophenone analogues in the carbazole series as potential atypical antipsychotics: Synthesis and determination of affinities at D2, 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors

We describe practical and efficient routes for synthesis of 2- aminomethyl-1,2,3,9-tetrahydro-4H-carbazol-4-ones using the Fischer indole synthesis or palladium-catalysed cyclization methodologies, as well as their affinities for D2, 5-HT(2A) and 5-HT(2C) receptors, and their activity at the 5-HT(2B) receptor. The most active compounds, 4b (QF 2003B) and 4c (QF 2004B), with a pK(i) (5-HT(2A)/D2) ratio of 1.28 show a potential antipsychotic profile according to Meltzer's classification. (C) 2000 Editions scientifiques et medicales Elsevier SAS.