266360-65-0Relevant academic research and scientific papers
Formation of 2'-deoxy-2-nitroadenosines by reaction of 2'-deoxyadenosines with copper(II) nitrate/acetic anhydride.
Kaiya, Toyo,Tanaka, Haruko,Kohda, Kohfuku
, p. 427 - 433 (2002)
Nitration of 9-substituted [ethyl, (Ac)2-2'-deoxyribosyl, (Ac)3-ribosyl] N6-acetyladenine derivatives with Cu(NO3)2.3H2O/Ac2O was examined. Nitration proceeded at the 2-position, although the yield was low. Removal of the acetyl groups gave 2'-deoxy-2-nitroadenosine derivatives.
Regioselective nitration of purine nucleosides: Synthesis of 2- nitroadenosine and 2-nitroinosine
Deghati, Paymaneh Y. F.,Wanner, Martin J.,Koomen, Gerrit-Jan
, p. 1291 - 1295 (2007/10/03)
Nitration reactions of 6-substituted purine nucleosides with tetrabutylammonium nitrate/trifluoroacetic anhydride (TBAN/TFAA) have been studied. This nitrating mixture selectively nitrates C-6 substituted purines at the 2-position, but the method is limited to substrates without NH or OH substituents. Acetylated 6-chloropurine riboside was cleanly nitrated (DCM, 0°C, 71%) and converted to nitro substituted adenosine and inosine in a few simple steps. (C) 2000 Elsevier Science Ltd.
