266688-41-9Relevant academic research and scientific papers
Glycosynthase-Mediated Assembly of Xylanase Substrates and Inhibitors
Goddard-Borger, Ethan D.,Fiege, Brigitte,Kwan, Emily M.,Withers, Stephen G.
experimental part, p. 1703 - 1711 (2012/06/29)
An exo-β-xylosidase mutant with glycosynthase activity was created to aid in the synthesis of xylanase substrates and inhibitors. Simple monosaccharides were easily elaborated into di-, tri- and tetrasaccharides by using this enzyme. Some products proved
Biocatalytic preparation of enantioenriched 3,4-dihydroxypiperidines and theoretical study of Candida antarctica lipase B enantioselectivity
Solares, Laura F.,Lavandera, Iván,Gotor-Fernández, Vicente,Brieva, Rosario,Gotor, Vicente
, p. 3284 - 3291 (2007/10/03)
Enzymatic acetylations of N-substituted cis- and trans-3,4- dihydroxypiperidine and hydrolysis of their diacetylated derivatives have been studied. High enantioselectivities are obtained with Pseudomonas cepacia lipase and Candida antarctica lipase B for
Enantioselective Trans Dihydroxylation of Nonactivated C-C Double Bonds of Aliphatic Heterocycles with Sphingomonas sp. HXN-200
Chang, Dongliang,Heringa, Maarten F.,Witholt, Bernard,Li, Zhi
, p. 8599 - 8606 (2007/10/03)
The bacterial strain Sphingomonas sp. HXN-200 was used to catalyze the trans dihydroxylation of N-substituted 1,2,5,6-tetrahydropyridines 1 and 3-pyrrolines 4 giving the corresponding 3,4-dihydroxypiperidines 3 and 3,4-dihydroxypyrrolidines 6, respectivel
Nanomolar versus millimolar inhibition by xylobiose-derived azasugars: Significant differences between two structurally distinct xylanases
Williams, Spencer J.,Hoos, Roland,Withers, Stephen G.
, p. 2223 - 2235 (2007/10/03)
The synthesis of xylobiose-derived nitrogen-containing inhibitors of xylanase is described starting with accessible precursors through efficient synthetic schemes. Four disaccharides were identified as powerful competitive inhibitors of the retaining fami
