266993-91-3Relevant academic research and scientific papers
BENZENE SULFONAMIDES AS CCR9 INHIBITORS
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Page/Page column 79; 80, (2015/07/15)
The present invention relates to compounds useful as CCR9 modulators, to compositions containing them, to methods of making them, and to methods of using them. In particular, the present invention relates to compounds capable of modulating the function of the CCR9 receptor by acting as partial agonists, antagonists or inverse agonists. Such compounds may be useful to treat, prevent or ameliorate a disease or condition associated with CCR9 activation, including inflammatory and immune disorder diseases or conditions such as inflammatory bowel diseases (IBD).
Recognition of CG interrupting site by W-shaped nucleoside analogs (WNA) having the pyrazole ring in an anti-parallel triplex DNA
Taniguchi, Yosuke,Uchida, Yuko,Takaki, Tomoko,Aoki, Eriko,Sasaki, Shigeki
experimental part, p. 6803 - 6810 (2010/02/28)
We have previously developed W-shaped nucleoside analogs (WNA) for recognition of TA and CG interrupting sites, which are the intrinsic limitation for the formation of a stable triplex DNA by the natural triplex-forming oligonucleotide (TFO). However, the
Synthesis of new pyrazolo[1,5-a]pyrimidines and pyrazolo[3,4-b]pyridines
Al-Mousawi,Mohammad,Elnagdi
, p. 989 - 991 (2007/10/03)
While 3(5)-aminopyrazole reacts with enaminonitrile to yield pyrazolo[1,5-a]pyrimidines, 3-amino-5-pyrazolone reacts with the same reagents to yields pyrazolo[3,4-b]pyridines.
