266997-55-1Relevant articles and documents
Inhibitors from rhubarb on lipopolysaccharide-induced nitric oxide production in macrophages: Structural requirements of stilbenes for the activity
Kageura, Tadashi,Matsuda, Hisashi,Morikawa, Toshio,Toguchida, Iwao,Harima, Shoichi,Oda, Mamiko,Yoshikawa, Masayuki
, p. 1887 - 1893 (2001)
By bioassay-guided separation, three stilbenes (rhapontigenin, piceatannol, and resveratrol), two stilbene glucoside gallates (rhaponticin 2″-O-gallate and rhaponticin 6″-O-gallate), and a naphthalene glucoside (torachrysone 8-O-β-D-glucopyranoside) with inhibitory activity against nitric oxide (NO) production in lipopolysaccharide-activated macrophages were isolated (IC50=11-69μM). The oxygen functions (-OH, -OCH3) of stilbenes at the benzene ring were essential for the activity. The glucoside moiety reduced the activity, while the α,β-double bond had no effect. Furthermore, the active stilbenes (rhapontigenin, piceatannol, and resveratrol) did not inhibit inducible NO synthase activity, but they inhibited nuclear factor-κB activation following expression of iNOS. Copyright
Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages
Matsuda, Hisashi,Kageura, Tadashi,Morikawa, Toshio,Toguchida, Iwao,Harima, Shoichi,Yoshikawa, Masayuki
, p. 323 - 327 (2007/10/03)
Two new anthraquinone glucosides [chrysophanol 8-O-β-D-(6'-galloyl)-glucopyranoside, aloe-emodin 1-O-β-D-glucopyranoside] together with various known stilbenes and their glucosides, anthraquinone glucosides, and a naphthalene glucoside were isolated from the rhizome of Rheum undulatum L. Three stilbenes (rhapontigenin, piceatannol, resveratrol), a naphthalene glucoside (torachrysone 8-O-β-D-glucopyranoside), and two stilbene glucoside gallates (rhaponticin 2'-O-gallate, rhaponticin 6'-O-gallate) showed inhibitory activity of NO production in lipopolysaccharide-activated macrophages. (IC50 = 11-69 μM). The oxygen functions (-OH,-OCH3) at the benzene ring were found to be essential to show the activity. Whereas, the glucoside moiety reduced the activity, while the α,β-double bond did not affect the activity. Furthermore, the active stilbenes (rhapontigenin, piceatannol, resveratrol) inhibited iNOS induction. (C) 2000 Elsevier Science Ltd. All rights reserved.