267-54-9

Basic information

• Product Name: [1,3]Dioxolo[4,5-f]-2,1-benzisoxazole(8CI,9CI)
• Synonyms: [1,3]Dioxolo[4,5-f]-2,1-benzisoxazole(8CI,9CI)
• CAS NO: 267-54-9
• Molecular Formula: C₈H₅NO₃
• Molecular Weight: 163.13
• Product Categories: OXAZOLE
• Mol File: 267-54-9.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 300.1°Cat760mmHg
• Flash Point: 135.3°C
• Appearance: /
• Density: 1.473g/cm³
• Vapor Pressure: 0.00204mmHg at 25°C
• Refractive Index: 1.655
• CAS DataBase Reference: [1,3]Dioxolo[4,5-f]-2,1-benzisoxazole(8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: [1,3]Dioxolo[4,5-f]-2,1-benzisoxazole(8CI,9CI)(267-54-9)
• EPA Substance Registry System: [1,3]Dioxolo[4,5-f]-2,1-benzisoxazole(8CI,9CI)(267-54-9)

Safety Data

• Hazardous Substances Data: 267-54-9(Hazardous Substances Data)

Usage

General Description

[1,3]Dioxolo[4,5-f]-2,1-benzisoxazole(8CI,9CI) is a chemical compound with the molecular formula C8H5NO2. It is a benzisoxazole derivative with a dioxolane ring attached to the benzene ring. [1,3]Dioxolo[4,5-f]-2,1-benzisoxazole(8CI,9CI) has potential applications in the pharmaceutical industry due to its unique structure and properties. It may have properties such as anti-inflammatory, analgesic, or other medicinal properties. However, further research and testing are needed to fully understand the potential uses and effects of this compound.

InChI:InChI=1/C8H5NO3/c1-5-3-12-9-6(5)2-8-7(1)10-4-11-8/h1-3H,4H2

Upstream product

• 712-97-0 6-nitro-1,3-benzodioxole-5-carbaldehyde 
• 1080661-03-5 N-[(E)-(6-nitro-1,3-benzodioxol-5-yl)methylene]aniline 
• 138306-34-0 [1-(6-Nitro-benzo[1,3]dioxol-5-yl)-meth-(E)-ylidene]-phenyl-amine 

Downstream Products

• 20332-16-5 4,5-methylenedioxyanthranilic acid 
• 97417-59-9 7-phenyl-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one 

Relevant articles and documents

I2-DMSO mediated oxidative amidation of methyl ketones with anthranils for the synthesis of: α -ketoamides

An I2-DMSO mediated oxidative amidation of methyl ketones using anthranils as masked N-nucleophiles has been developed for the direct synthesis of α-ketoamides with high atom-economy. This metal-free process involves reductive N-O bond cleavage of anthranils and oxidative C-N bond formation of methyl ketones under mild conditions. The iodo group and electrophilic formyl group provide multiple possibilities for further functionalization of α-ketoamides.

Access to acridones by tandem copper(i)-catalyzed electrophilic amination/Ag(i)-mediated oxidative annulation of anthranils with arylboronic acids

An efficient and practical approach for the synthesis of medicinally important acridones was developed from anthranils and commercially available arylboronic acids by a tandem copper(i)-catalyzed electrophilic amination/Ag(i)-mediated oxidative annulation strategy. This new and straightforward protocol displayed a broad substrate scope (25 examples) and high functional group tolerance. What's more, a possible mechanistic proposal was also presented.

Gold-Catalyzed Intermolecular Formal [4 + 2 + 2]-Cycloaddition of Anthranils with Allenamides

The construction of eight-membered rings is a challenging issue due to unfavorable transannular strain and entropic barriers. We report herein a gold-catalyzed formal [4 + 2 + 2] cycloaddition reaction of anthranils with allenamides to deliver oxa-bridged eight-membered heterocycles in accepted yields with unique E/Z configuration. Moreover, the asymmetric [4 + 2 + 2] cycloaddition by using chiral phosphoramidite gold catalyst has also been conducted.