267011-39-2

Basic information

• Product Name: (R)-5-tert-butyldiphenylsilyloxy-1,2-O-isopropylidene-pentane-1,2-ol
• Synonyms: (R)-5-tert-butyldiphenylsilyloxy-1,2-O-isopropylidene-pentane-1,2-ol
• CAS NO: 267011-39-2
• Molecular Weight: 398.618
• Mol File: 267011-39-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-5-tert-butyldiphenylsilyloxy-1,2-O-isopropylidene-pentane-1,2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-tert-butyldiphenylsilyloxy-1,2-O-isopropylidene-pentane-1,2-ol(267011-39-2)
• EPA Substance Registry System: (R)-5-tert-butyldiphenylsilyloxy-1,2-O-isopropylidene-pentane-1,2-ol(267011-39-2)

Safety Data

• Hazardous Substances Data: 267011-39-2(Hazardous Substances Data)

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 133008-08-9 (4R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propan-1-ol 

Downstream Products

• 267011-41-6 (R)-5-tert-butyldiphenylsilyloxy-2-methoxymethoxypentan-1-ol 
• 267011-42-7 (R)-5-tert-butyldiphenylsilyloxy-1-iodo-2-methoxymethoxypentane 
• 267011-40-5 (R)-5-tert-butyldiphenylsilyloxypentane-1,2-diol 

Relevant articles and documents

Total synthesis of a nonclassical bioactive acetogenin, (+)-muconin

A convergent total synthesis of the tetrahydropyran-bearing acetogenin (+)-muconin 1 is described. All five chiral building blocks 7, 9, 17, 21, and 29 were prepared from D-glutamic acid, respectively. Four out of them were used to furnish the alkyne 16 and the iodoalkyne 33, respectively, and palladium(0)-mediated cross-coupling of alkynes 16 and 33, followed by hydrogenation, afforded 36. Simultaneous deprotection of the MOM and TBS groups in 36 with BF3·Et2O in the presence of Me2S provided (+)-muconin 1. (C) 2000 Elsevier Science Ltd.