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(R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-PROPANOL, with the molecular formula C9H18O2, is a colorless liquid chemical compound. It is recognized for its versatility in forming stable complexes with various organic molecules, making it a valuable asset in the pharmaceutical and chemical industries. Its low toxicity and high stability further contribute to its popularity in these sectors.

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  • 133008-08-9 Structure
  • Basic information

    1. Product Name: (R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-PROPANOL
    2. Synonyms: 1,3-DIOXOLANE-4-PROPANOL, 2,2-DIMETHYL-, (R)-;(R)-4,5-ISOPROPYLIDENE-1-PENTANOL;(R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-PROPANOL;(4R)-2 2-DIMETHYL-1 3-DIOXOLANE-4-PROPA&;(4R)-2,2-Dimethyl-1,3-dioxolane-4-(3-propanol);(4R)-2,2-Dimethyl-1,3-dioxolane-4-propanol
    3. CAS NO:133008-08-9
    4. Molecular Formula: C8H16O3
    5. Molecular Weight: 160.21
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 133008-08-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 221.017 °C at 760 mmHg
    3. Flash Point: 103.746 °C
    4. Appearance: /
    5. Density: 0.996 g/cm3
    6. Vapor Pressure: 0.023mmHg at 25°C
    7. Refractive Index: 1.434
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: (R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-PROPANOL(CAS DataBase Reference)
    11. NIST Chemistry Reference: (R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-PROPANOL(133008-08-9)
    12. EPA Substance Registry System: (R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-PROPANOL(133008-08-9)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 37/38-41-43
    3. Safety Statements: 26-36/37/39
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 133008-08-9(Hazardous Substances Data)

133008-08-9 Usage

Uses

Used in Chemical Industry:
(R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-PROPANOL is used as a solvent for various industrial applications, leveraging its ability to dissolve a wide range of substances and facilitate chemical reactions.
Used in Pharmaceutical Industry:
(R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-PROPANOL is used as a chiral resolving agent in organic synthesis, playing a crucial role in the production of enantiomerically pure compounds, which are essential for the development of many pharmaceutical drugs.
Used in Research and Development:
(R)-2,2-DIMETHYL-1,3-DIOXOLANE-4-PROPANOL is employed in research settings for the study of its interactions with organic molecules, potentially leading to new discoveries and applications in the fields of chemistry and materials science.

Check Digit Verification of cas no

The CAS Registry Mumber 133008-08-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,0,0 and 8 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 133008-08:
(8*1)+(7*3)+(6*3)+(5*0)+(4*0)+(3*8)+(2*0)+(1*8)=79
79 % 10 = 9
So 133008-08-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H16O3/c1-8(2)10-6-7(11-8)4-3-5-9/h7,9H,3-6H2,1-2H3/t7-/m1/s1

133008-08-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propan-1-ol

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:133008-08-9 SDS

133008-08-9Relevant articles and documents

Reductive spiroannulation of nitriles with secondary electrophiles

Morin, Matthew D.,Rychnovsky, Scott D.

, p. 2051 - 2053 (2005)

(Chemical Equation Presented) The scope of reductive decyanation and spiroannulation reactions has been expanded to include secondary electrophiles for potentially useful transformations. Secondary phosphates and chlorides, as well as terminal epoxides, c

MONOBACTAM COMPOUNDS AND USE THEREFOR

-

, (2022/01/12)

Monobactam compounds and a use therefor. Specifically provided are chemical compounds represented by formula (I) or isomers, pharmaceutically acceptable salts, solvates, crystals, or prodrugs thereof, preparation methods therefor, pharmaceutical compositions containing said compounds, and a use of said compounds or compositions in treating bacterial infection. The present compounds feature excellent antibacterial activity, and have great hopes of becoming a therapeutic agent for bacterial infection.

One-pot, two-step synthesis of unnatural α-amino acids involving the exhaustive aerobic oxidation of 1,2-diols

Inada, Haruki,Furukawa, Keisuke,Shibuya, Masatoshi,Yamamoto, Yoshihiko

, p. 15105 - 15108 (2019/12/26)

Herein, we report the nor-AZADO-catalyzed exhaustive aerobic oxidations of 1,2-diols to α-keto acids. Combining oxidation with transamination using dl-2-phenylglycine led to the synthesis of free α-amino acids (AAs) in one pot. This method enables the rapid and flexible preparation of a variety of valuable unnatural AAs, such as fluorescent AAs, photoactivatable AAs, and other functional AAs for bioorthogonal reactions.

ANGIOTENSIN II RECEPTOR ANTAGONISTS

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Page/Page column 28, (2008/12/06)

A compound having the structure (Formula I), wherein R is an angiotensin receptor antagonist active group, Y is -Y1-Y2-Y3-Y4-Y5.; Y1 is C(R1R2); R1 is selected from the group consisting of hydrogen and C1-4 alkyl; R2 is selected from the group consisting of hydrogen, C1-4 alkyl, and -0C(0)C1-4 alkyl; Y2 is O or CH2; Y3 is C(O) or CH2; Y4 is O or CH2; Y5 is -(CH2) 1-2-(X)0-l-(CH2)0-l- or is absent; X is -O- or - CR3R4-; and R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.

Unified total synthesis of pteriatoxins and their diastereomers

Matsuura, Fumiyoshi,Peters, Rene,Anada, Masahiro,Harried, Scott S.,Hao, Junliang,Kishi, Yoshito

, p. 7463 - 7465 (2007/10/03)

A unified total synthesis is reported to access all of the possible diastereomers of pteriatoxins A-C, with the use of an intramolecular Diels-Alder reaction as the key step to form the carbo-macrocyclic core structure. The C34/C35-diol protecting groups were found to have significant effects on both the exo/endo-selectivity and the exo-facial selectivity of the intramolecular Diels-Alder process. Copyright

Stereoselective synthesis of chiral tetrahydrofurans with potent 5-LO inhibitory activity

Sharma,Punna, Sreenivas,Krishna, Palakodety Radha,Chorghade, Mukund S.,Ley, Steven V.

, p. 1125 - 1133 (2007/10/03)

Chiral glyceraldehydes have been exploited for the design of convenient and scalable synthetic approaches to chiral tetrahydrofurans, which have potential as potent 5-lipoxygenase (5-LO) inhibitors. The synthesis of all four possible stereoisomers by a general methodology is reported; wherein the chirons derived from the glyceraldehyde derivatives on reaction with homopropargyl ether, cyclization and further reactions gave the targets.

Stereoselective syntheses of pharmaceutically relevant chiral tetrahydrofurans from (S)- and (R)-glyceraldehyde derivatives

Sharma,Punna, Sreenivas,Rajendra Prasad,Krishna, Palakodety Radna,Chorghade, Mukund S.,Ley, Steven V.

, p. 1113 - 1123 (2007/10/03)

A practically simple and flexible method of making chiral tetrahydrofurans of therapeutic relevance is reported from glyceraldehyde derivatives as chiral synthons. One of the stereocentres is derived from glyceraldehyde derivatives, while the other one is introduced by Sharpless asymmetric epoxidation using either (+)- or (-)-DIPT.

Synthesis of the spiroacetal fragment of broussonetine H

Brimble, Margaret A.,Park, Jae H.,Taylor, Carol M.

, p. 5861 - 5868 (2007/10/03)

(2S,6S)-2-(3-Bromopropyl)-1,7-dioxaspiro[5.5]undecane 3 was prepared by the addition of the acetylide derived from (4S)-4-benzyloxy-7-tert-butyldiphenylsilyloxyhep-1-yne 8 to δ-valerolactone 6 followed by treatment with hydrogen and palladium on charcoal which effected hydrogenation of the alkyne, hydrogenolysis of the benzyl ether and subsequent spiroacetal formation. The (4S)-stereochemistry in acetylene 8 was established by addition of trimethylsilylacetylene 10 to (2S)-epoxide 9, which in turn is derived from L-glutamic acid 11.

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