2672-41-5

Usage

Uses

Used in Pharmaceutical Industry:
(4aR,4bS,6aR,7R,9aS,9bS,11aR)-4a,6a-dimethyl-7-[(2R)-6-methylheptan-2-yl]hexadecahydroindeno[5,4-f]chromene is used as a potential pharmaceutical candidate for [application reason] due to its complex structure and multiple stereocenters, which may contribute to its biological activity.
Used in Chemical Research:
In the field of chemical research, (4aR,4bS,6aR,7R,9aS,9bS,11aR)-4a,6a-dimethyl-7-[(2R)-6-methylheptan-2-yl]hexadecahydroindeno[5,4-f]chromene is used as a subject of study for [application reason] to understand its stereochemistry, functional groups, and potential interactions with biological systems.

Upstream product

• 566-51-8 Cholestan-4-one 
• 93789-83-4 Formic acid (3R,3aR,5aS,6R,7R,9aS,9bS)-3-((R)-1,5-dimethyl-hexyl)-6-(3-iodo-propyl)-3a,6-dimethyl-dodecahydro-cyclopenta[a]naphthalen-7-yl ester 
• 58323-66-3 4a-oxa-A-homo-5α-cholestan-4-one 
• 93789-75-4 4a-oxa-A-homo-5α-cholestan-4-ol 

Downstream Products

• 2061-74-7 4-oxa-5α-cholestan-3-one 

Relevant academic research and scientific papers

Photoinduced Transformations. 77. A Four-Step Substitution of a Carbonyl Group of Steroidal Ketones by an Oxygen Atom. A New Method for the Synthesis of Cyclic Ethers

We set out to describe a new and versatile method for transforming steroidal five- and six-memered cyclic ketones as a starting materials into steroidal cyclic ethers with the same ring size via four steps; Baeyer-Villiger oxidation of steroidal ketone to a lactone followed by its reduction with DIBAL gives the corresponding lactol.The irradiation of the hypoiodite generated in situ by means of the reaction of the lactol by an excess of mercury(II)oxide-iodine and pyridine in benzene gives formates arising from a regiospecific β-scission of th C-C bond.These formates can read ily be transformed into oxasteroids by treatment with a complex metal hydride or methyllithium.By this new method a variety of steroidal cyclic ketones were transformed into the corresponding cyclic ethers in a good overall yields.The stereochemical integrity of the chiral center adjacent to the carbonyl group of the starting cyclic ketones is maintained throughout this transformation.

REPLACEMENT OF A CARBONYL GROUP OF CYCLIC KETONES BY AN OXYGEN ATOM: A FOUR-STEP TRANSFORMATION OF CYCLIC KETONES INTO CYCLIC ETHERS

We describe a new and versatile method for transforming cyclic ketones into cyclic ethers with the same ring size in which the chirality adjacent to the carbonyl group of the ketones is retained.