267220-58-6

Basic information

• Product Name: 2-Piperidinecarboxylicacid,1-(cyanomethyl)-(9CI)
• Synonyms: 2-Piperidinecarboxylicacid,1-(cyanomethyl)-(9CI);1-(Cyanomethyl)-2-piperidinecarboxylic acid
• CAS NO: 267220-58-6
• Molecular Formula: C8H12N2O2
• Molecular Weight: 168.19308
• Product Categories: GLYCINESCAFFOLD
• Mol File: 267220-58-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.195
• CAS DataBase Reference: 2-Piperidinecarboxylicacid,1-(cyanomethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperidinecarboxylicacid,1-(cyanomethyl)-(9CI)(267220-58-6)
• EPA Substance Registry System: 2-Piperidinecarboxylicacid,1-(cyanomethyl)-(9CI)(267220-58-6)

Safety Data

• Hazardous Substances Data: 267220-58-6(Hazardous Substances Data)

Upstream product

• 142-84-7 di-n-propylamine 
• 267220-57-5 cyanomethyl N-(cyanomethyl)piperidine-2-carboxylate 
• 4043-87-2 pipecolic Acid 

Relevant articles and documents

Syntheses of R and S isomers of AF-DX 384, a selective antagonist of muscarinic M2 receptors

Enantiomers of 5,11-dihydro-11-[2-[2-[(N,N-dipropylaminomethyl)piperidin-1-yl]ethylamino]-carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one (AF-DX 384) 1, have been synthesized from (S)-(+) and (R)-(-)-2-[N,N-dipropylaminomethyl]piperidine 4. The enantiomeric excess of 1 has been determined by capillary electrophoresis by using the α-highly sulphated cyclodextrin (α-HSCD) as chiral selector within the running electrolyte. (S)-(+)-(4) was prepared from (S)-(-)-pipecolic acid in a 4-step procedure (overall yield: 30%, ee: 99%) and (R)-(-)-AF-DX 384 from (R)-(+)-pipecolic acid. The (R)-(-) isomer exhibited in vitro a 23-fold higher affinity than its enantiomer (S)-(+) towards muscarinic receptors of subtype 2. Copyright (C) 2000.