267230-41-1

Usage

Hydrochloride Salt

The compound is a hydrochloride salt, indicating the presence of a hydrogen chloride (HCl) molecule.

Complex Structure

The compound consists of pyrrolidinedicarboxylic acid, amines, and various esters, which contribute to its complex structure.

Chiral Center

The presence of (1R) and (3R,4S) in the name suggests that the compound has a chiral center, meaning it has optical isomers.

Optical Isomers

The compound has optical isomers due to its chiral center, which can have different biological activities and properties.

Potential Applications

Given its complex and potentially biologically active composition, the compound may have applications in pharmaceuticals or other industries.

Further Study

The specific properties, uses, and potential effects of the compound would require further study and analysis to fully understand its characteristics and potential applications.

Stereochemistry

The compound's stereochemistry, defined by the (1R) and (3R,4S) designations, plays a crucial role in its biological activity and potential applications.

Ester Functionality

The presence of an ester group (-COO-) in the compound suggests potential reactivity and involvement in various chemical reactions.

Amino Group

The compound contains an amino group (-NH2), which can participate in various chemical reactions and interactions, such as hydrogen bonding and salt formation.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 14719-37-0 ethyl 2-(tert-butoxycarbonylamino)acetate 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 146256-98-6 4-oxo-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Relevant academic research and scientific papers

3-Aminopyrrolidine-4-carboxylic acid as versatile handle for internal labeling of pyrrolidinyl PNA

Conformationally restricted pyrrolidinyl PNAs with an a/b-dipeptide backbone consisting of a nucleobase- modified proline and a cyclic five-membered amino acid spacer such as (1S,2S)-2-aminocyclopentanecarboxylic acid (ACPC) (acpcPNA) can form very stable hybrids with DNA with high Watson-Crick base pairing specificity. This work aims to explore the effect of incorporating 3-aminopyrrolidine-4-carboxylic acid (APC), whi h is isosteric to the ACPC spacer, into the acpcPNA. It is expected that the modification should not negatively affect the DNA binding properties, and that the additional nitrogen atom in the APC should provide a handle for internal modification. Orthogonally-protected (N3-Fmoc/N1-Boc and N3-Fmoc/N1-Tfa) APC monomers have been successfully synthesized and incorporated into the acpcPNA by Fmoc-solid-phase peptide synthesis. Tm, UV and CD spectroscopy confirmed that the (3R,4S)-APC could substitute the (1S,2S)-ACPC spacer in the acpcPNA with only slightly decreasing the stability of the hybrids formed between the modified acpc/apcPNA and DNA. In contrast, the (3S,4R) enantiomer of APC caused substantial destabilization of the hybrids. Furthermore, a successful on-solid-support internal labeling of the acpc/apcPNA via amide bond formation between pyrene-1-carboxylic acid or 4-(pyrene-1-yl) butyric acid and the pyrrolidine nitrogen atom of the APC spacer has been demonstrated. Fluorescence properties of the pyrene-labeled acpc/apcPNAs are sensitive to their hybridization states and can readily distinguish between complementary and single-mismatched DNA targets.

Glycosylated foldamers to probe the carbohydrate-carbohydrate interaction

The synthesis of a triglycosylated helical foldamer based on a combination of cyclopentyl- and pyrrolidinyl-based amino acids is described. This structure is stable in water, maintaining as it does a series of carbohydrate units in proximity to one another, and represents the basis of a new approach to the study of carbohydrate-carbohydrate interactions. Copyright