14719-37-0

Basic information

• Product Name: TERT-BUTOXYCARBONYLAMINO-ACETIC ACID ETHYL ESTER
• Synonyms: N-Boc-glycine Ethyl Ester;Ethyl 2-(tert-butoxycarbonylaMino)acetate;Glycine, N-[(1,1-diMethylethoxy)carbonyl]-, ethyl ester;N-(tert-butoxycarbonyl)glycine ethyl ester;Ethyl [(tert-butoxycarbonyl)amino]acetate;EthylN-(tert-butoxycarbonyl)glycinate;2-(tert-butoxycarbonylamino)acetic acid ethyl ester;2-[(tert-butoxy-oxomethyl)amino]acetic acid ethyl ester
• CAS NO: 14719-37-0
• Molecular Formula: C₉H₁₇NO₄
• Molecular Weight: 203.24
• EINECS: 1533716-785-6
• Mol File: 14719-37-0.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 97°C/0.7mmHg(lit.)
• Flash Point: 125.5oC
• Appearance: Colorless/Oily Liquid
• Density: 1.053g/cm3
• Vapor Pressure: 0.00306mmHg at 25°C
• Refractive Index: 1.4350 to 1.4390
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 11.18±0.46(Predicted)
• CAS DataBase Reference: TERT-BUTOXYCARBONYLAMINO-ACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTOXYCARBONYLAMINO-ACETIC ACID ETHYL ESTER(14719-37-0)
• EPA Substance Registry System: TERT-BUTOXYCARBONYLAMINO-ACETIC ACID ETHYL ESTER(14719-37-0)

Safety Data

• Hazardous Substances Data: 14719-37-0(Hazardous Substances Data)

Usage

General Description

Tert-butoxycarbonylamino-acetic acid ethyl ester is an organic chemical compound primarily used in research and laboratory settings. It is categorized as a carbamic acid and an ester, characterized by the presence of a carbonyl group (C=O) and an ester group (-COO-). It is a member of the chemical family of protective reagents utilized in peptide synthesis, where it is adopted to protect the α-amino group of amino acids in order to prevent undesired side reactions. The protective group is later removed after the intended reactions are complete. Overall, it's an essential tool in the field of organic chemistry and biochemistry for its role in efficient and precise peptide synthesis.

InChI:InChI=1/C9H17NO4/c1-5-13-7(11)6-10-8(12)14-9(2,3)4/h5-6H2,1-4H3,(H,10,12)

Upstream product

• 66389-79-5 N-tert.-Butoxycarbonyl-N-methoxycarbonylglycinaethylester 
• 3655-05-8 tert-butoxycarbonylglycine p-nitrophenylester 
• 16679-94-0 N-[(phenylmethoxy)carbonyl]-L-tyrosine 
• 50903-47-4 perfluorophenyl 2-((tert-butoxycarbonyl)amino)acetate 
• 623-33-6 glycine ethyl ester hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 870-46-2 t-butoxycarbonylhydrazine 
• 459-73-4 GlyOEt*HCl 
• 4530-20-5 BOC-glycine 
• 541-41-3 chloroformic acid ethyl ester 
• 219580-24-2 3,5-Dimethyl-pyrazole-1-carboxylic acid tert-butyl ester 
• 219580-32-2 tert-butyl 1H-pyrazole-1-carboxylate 
• 64-17-5 ethanol 
• 53588-96-8 Malonsaeure-monoetylester-azid 

Downstream Products

• 552335-71-4 Boc-L-2-amino-7-octenoic acid 
• 1219015-26-5 (R)-2-((tert-butoxycarbonyl)amino)oct-7-enoic acid 
• 31925-29-8 (2S,3R)-2-amino-3-hydroxy-3-(4-methylsulfonylphenyl)propionic acid ethyl ester 
• 36983-12-7 D-threo-p-methylsulfonylphenylserine ethyl ester 
• 4530-20-5 BOC-glycine 
• 253196-35-9 (N-tert-Butoxycarbonyl)-3-methyl-1,2,4-oxadiazol-5-ylmethylamine 
• 1449117-74-1 ethyl 1-(tert-butoxycarbonyl)-4-ureido-2,5-dihydro-1H-pyrrole-3-carboxylate 
• 951626-01-0 ethyl 1-(tert-butoxycarbonyl)-4-amino-2,5-dihydro-1H-pyrrole-3-carboxylate 
• 98977-38-9 ethyl (+/-)-1-(tert-butyloxycarbonyl)-3-oxoperhydroazepine-4-carboxylate 
• 1454843-77-6 (±)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid 
• 1129634-44-1 (6S)-5-[(tert-butoxy)carbonyl]-5-azaspiro[2.4]heptane-6-carboxylic acid 
• 1011269-18-3 (tert-butoxycarbonyl-phenylethynyl-amino)-acetic acid ethyl ester 
• 1011269-25-2 (tert-butoxycarbonyl-cyclohex-1-enylethynyl-amino)-acetic acid ethyl ester 

Relevant articles and documents

Design and synthesis novel amide derivatives containing an 1,3,4-oxadiazole moiety as potential antibacterial agents

To find new antibacterial agents, 25 novel amide derivatives containing an 1,3,4-oxadiazole moiety were designed and synthesized, and their antibacterial activity against Xanthomonas oryzae pv. oryzicola (Xoc) and Xanthomonas oryzae pv. oryzae (Xoo) were tested. Interestingly, all target compounds showed excellent antibacterial activities against Xoc and Xoo. The EC50 values of compounds 1–25 against Xoc and Xoo were 1.2–4.0?mg/L and 0.5–2.3?mg/L, respectively, which were significantly superior to those of the thiodiazole copper (95.1 and 89.0?mg/L) and bismerthhibol (73.8 and 68.8?mg/L). For example, the EC50 values of compound 16 against Xoc and Xoo were 1.7 and 0.5?mg/L, respectively. Meanwhile, the curative and protection activity of compound 16 against rice bacterial leaf blight were 42.4% and 42.1%, respectively, which were superior to the control of jiahuangxianjunzuo (34.1% and 32.6%) and thiodiazole copper (33.0% and 27.1%). In addition, compound 16 might suppress the cell growth of Xoo by inhibiting the production of extracellular polysaccharide, the formation of biofilm, changes the cell membrane permeability, and cell surface morphology.

IONIZABLE CATIONIC LIPID FOR RNA DELIVERY

What is described is a compound of formula I consisting of a compound in which R1 is a branched chain alkyl consisting of 10 to 31 carbons; R2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons; L1 and L2 are the same or different, each a linear alkylene of 1 to 20 carbons or a linear alkenylene of 2 to 20 carbons; X1 is S or O; R3 is a linear or branched alkylene consisting of 1 to 6 carbons; and R4 and R5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.

BICYCLIC AMINES AS NOVEL JAK KINASE INHIBITORS

The present invention relates to a compound according to formula (I) wherein R1 represents alkyl; n is 1 or 2; R2 is selected from the group consisting of hydrogen, cyano, -SO2Ra, -SO2NRbR