26725-96-2Relevant academic research and scientific papers
Chitosan nanofiber-catalyzed highly selective Knoevenagel condensation in aqueous methanol
Hatakeyama, Mayumi,Hirayama, Yusaku,Kanomata, Kyohei,Kitaoka, Takuya
, p. 26771 - 26776 (2020)
A chitosan nanofiber (CsNF)-catalyzed Knoevenagel reaction in green solvent, namely aqueous methanol, was investigated. CsNFs solely catalyzed the desired C-C bond formations in high yield with high selectivity, while conventional small-molecule amines, such as n-hexylamine and triethylamine, inevitably promoted transesterification to produce a large amount of solvolysis byproducts. Structural and chemical analyses of CsNFs suggested that the unique nanoarchitecture, in which chitosan molecules were bundled to ensure the high accessibility of substrates to catalytic sites, was critical to the highly efficient Knoevenagel condensation. The products were obtained in high purity without solvent-consuming purification, and the CsNF catalyst was easily removed and recycled. This study highlights a novel and promising function of CsNFs in green catalysis as emerging polysaccharide-based nanofibers.
Diastereoselective Synthesis of Spiro[2.3]hexanes from Methylenecyclopropane and Cyanoalkenes Catalyzed by a Tin-Ate Complex
Suzuki, Itaru,Shimazu, Jun-ya,Tsunoi, Shinji,Shibata, Ikuya
supporting information, p. 3658 - 3661 (2019/06/17)
A diastereoselective synthesis of spiro[2.3]hexane catalyzed by Sn and Mg halides was developed from a combination of methylenecyclopropane and cyanoalkene bearing an ester group. The selectivity was affected by the size of the halogen in the catalyst and
