26738-92-1Relevant academic research and scientific papers
End group-functionalization and synthesis of block-copolythiophenes by modified nickel initiators
Smeets, Alfons,Willot, Pieter,De Winter, Julien,Gerbaux, Pascal,Verbiest, Thierry,Koeckelberghs, Guy
scheme or table, p. 6017 - 6025 (2012/03/08)
Polythiophenes with alcohol, tosylate, azide, ethynylene, carboxylic acid, and amine end groups were prepared by a combination of functionalized nickel initiators and postpolymerization reactions. The azide and ethynylene polymers were subsequently used in a click reaction to produce a conjugated block copolymer. Finally, a conjugated triblock-copolymer was synthesized by means of a chain growth polymerization initiated by a binuclear nickel initiator.
"clickable" elastins: Elastin-like polypeptides functionalized with azide or alkyne groups
Teeuwen, Rosalie L. M.,Van Berkel, Sander S.,Van Dulmen, Tim H. H.,Schoffelen, Sanne,Meeuwissen, Silvie A.,Zuilhof, Han,De Wolf, Frits A.,Van Hest, Jan C. M.
supporting information; experimental part, p. 4022 - 4024 (2009/12/24)
Elastin-like polypeptides (ELPs) functionalized with azide or alkyne groups were produced biosynthetically and coupled via the Cu-catalyzed azide-alkyne cycloaddition to a variety of (bio)molecules.
PROCESS FOR THE PREPARATION OF 1,4,5-TRISUBSTITUTED TRIAZOLES AND 3,4,5-TRISUBSTITUTED TRIAZOLES
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Page/Page column 48, (2008/12/06)
The present invention relates to a process for the preparation of 1,4,5- trisubstituted triazoles and 3,4,5-trisubstituted triazoles according to Formulas (Ia) and 5 (Ib), and mesomers and tautomers thereof, wherein a compound according to Formula (II) or Formula (III): is reacted with a compound according to Formula (IV). The process is very useful for the selective and site-specific addition of azide compounds to optionally activated alkynes to form 1,4,5-trisubstuted triazoles and mesomers and tautomers thereof and the application of this process to the covalent functionalisation of biomolecules.
AMINO ALCOHOL DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USE OF THESE
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Page/Page column 40, (2008/06/13)
The present invention provides compounds represented by general formula (I): a prodrug thereof, or pharmaceutical acceptable salts thereof, wherein R1 is hydrogen or lower alkyl; each of R2 and R3 is independently hydrogen or lower alkyl; each of R4, R5 and R6 is independently hydrogen, halogen, lower alkyl or lower alkoxy; R7 is hydrogen or lower alkyl; R8 is hydrogen, halogen, lower alkyl, lower alkoxy, etc; R9 is -COR10, -A1-COR10, -O-A2-COR10, etc; Ar is optionally substituted phenyl or heteroaryl; and A is a bond, -OCH2-, etc, which exhibit potent and selective β3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.
AMINO ALCOHOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND USE THEREOF
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Page/Page column 32, (2008/06/13)
The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen or lower alkyl; R3 R4, R5 and R6 are each hydrogen, halogen, lower alkyl or lower alkoxy; R7 and R8 are each hydrogen, halogen, lower alkyl, halo-lower alkyl, lower alkoxy, cycloalkyl, aryl, heteroaryl, cyano, a hydroxyl group, lower acyl, carboxy or the like; R9 is -C(O)-R10, -A1-C(O)-R10, -O-A2-C(O)-R10 or a tetrazol-5-yl group, which exhibit potent and selective β3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.
