26739-87-7

Upstream product

• 1619-58-5 2-cyano-butyric acid ethyl ester 
• 74-88-4 methyl iodide 
• 74-96-4 ethyl bromide 
• 75-03-6 ethyl iodide 
• 1572-99-2 ethyl 2-cyanopropionate 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 

Downstream Products

• 308335-56-0 ethyl 2-methyl-2-phenylselanylbutanoate 
• 1309660-28-3 ethyl 4-(2-cyanobutan-2-yl)benzoate 
• 1426841-32-8 2-ethyl-2-methyl-4-phenylbut-3-ynenitrile 
• 1426841-35-1 2-ethyl-4-(4-methoxyphenyl)-2-methylbut-3-ynenitrile 
• 1426841-37-3 2-ethyl-4-(4-ethylphenyl)-2-methylbut-3-ynenitrile 
• 1426841-39-5 4-(4-chlorophenyl)-2-ethyl-2-methylbut-3-ynenitrile 
• 1426841-41-9 2-ethyl-4-(4-fluorophenyl)-2-methylbut-3-ynenitrile 

Relevant academic research and scientific papers

POLO-LIKE KINASE INHIBITORS

Compounds of the following formula are provided for use with kinases, wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful

Efficient preparation of α,α-dialkyl-α-(phenylselanyl) acetates and α,β-unsaturated esters from the corresponding α,α-dialkyl-α-cyanoacetates by a lithium naphthalenide induced reductive selenenylation process

An array of α,α-dialkyl-α-(phenylselanyl)acetates has been synthesized very efficiently from readily available α,α- dialkyl-α-cyanoacetates, by use of lithium naphthalenide induced reductive α-selenenylation as a key operation. Moreover, the selanyl esters thus generated in situ could be converted further, in a one-pot treatment with hydrogen peroxide and acetic acid, into the corresponding α,β- unsaturated esters in moderate to high yields. The C=C bond formation was highly regio- and/or diastereoselective in some cases. Georg Thieme Verlag Stuttgart.

Synthesis of N-bonded enolatoruthenium(II) by oxidative addition of alkyl cyanocarboxylate to a ruthenium(0) complex

Reaction of a zero-valent ruthenium complex [Ru(cot)(cod)] 1 (cod = 1,5-cyclooctadiene; cot = 1,3,5-cyclooctatriene) with alkyl cyanoacetate in the presence of mono- and bi-dentate tertiary phosphines gave a series of hydrido(enolato)-ruthenium(n) complexes: mer-[RuH(NCCHCO2Et)(NCCH2CO2Et)(PPh 3)3] 2; trans-[RuH(NCCHCO2Et)(cod)-(dppe)] 3 (dppe = Ph2PCH2CH2PPh2); trans-[RuH(NCCR1CO2R2)(dppe)2] (R1 = H, R2 = Et 4a: or Pri 4b; R1 = Me, R2 = Et 4c) and trans-[RuH(NCCMeCO2Et)(PMePh2)4] 5. The molecular structure of 3 shows that the enolato ligand co-ordinates to the ruthenium centre via the cyano group in an octahedral geometry. These hydrido-(enolato)ruthenium(II) complexes catalyse Michael and Knoeevenagel reactions under neutral and mild conditions. The Royal Society of Chemistry 1999.