26739-87-7

Basic information

• Product Name: Butanoic acid, 2-cyano-2-methyl-, ethyl ester
• Synonyms: 2-cyano-2-methyl-butyric acid ethyl ester;Butanoic acid,2-cyano-2-methyl-,ethyl ester;2-Cyan-2-methyl-buttersaeure-aethylester
• CAS NO: 26739-87-7
• Molecular Formula: C8H13NO2
• Molecular Weight: 155.19400
• Mol File: 26739-87-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 198 °C
• Density: 0.985±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Butanoic acid, 2-cyano-2-methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-cyano-2-methyl-, ethyl ester(26739-87-7)
• EPA Substance Registry System: Butanoic acid, 2-cyano-2-methyl-, ethyl ester(26739-87-7)

Safety Data

• Hazardous Substances Data: 26739-87-7(Hazardous Substances Data)

Upstream product

• 74-96-4 ethyl bromide 
• 1572-99-2 ethyl 2-cyanopropionate 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 1619-58-5 2-cyano-butyric acid ethyl ester 
• 74-88-4 methyl iodide 
• 75-03-6 ethyl iodide 

Downstream Products

• 308335-56-0 ethyl 2-methyl-2-phenylselanylbutanoate 
• 1309660-28-3 ethyl 4-(2-cyanobutan-2-yl)benzoate 
• 1426841-32-8 2-ethyl-2-methyl-4-phenylbut-3-ynenitrile 
• 1426841-35-1 2-ethyl-4-(4-methoxyphenyl)-2-methylbut-3-ynenitrile 
• 1426841-37-3 2-ethyl-4-(4-ethylphenyl)-2-methylbut-3-ynenitrile 
• 1426841-39-5 4-(4-chlorophenyl)-2-ethyl-2-methylbut-3-ynenitrile 
• 1426841-41-9 2-ethyl-4-(4-fluorophenyl)-2-methylbut-3-ynenitrile 

Relevant articles and documents

POLO-LIKE KINASE INHIBITORS

Compounds of the following formula are provided for use with kinases, wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful

Synthesis of N-bonded enolatoruthenium(II) by oxidative addition of alkyl cyanocarboxylate to a ruthenium(0) complex

Reaction of a zero-valent ruthenium complex [Ru(cot)(cod)] 1 (cod = 1,5-cyclooctadiene; cot = 1,3,5-cyclooctatriene) with alkyl cyanoacetate in the presence of mono- and bi-dentate tertiary phosphines gave a series of hydrido(enolato)-ruthenium(n) complexes: mer-[RuH(NCCHCO2Et)(NCCH2CO2Et)(PPh 3)3] 2; trans-[RuH(NCCHCO2Et)(cod)-(dppe)] 3 (dppe = Ph2PCH2CH2PPh2); trans-[RuH(NCCR1CO2R2)(dppe)2] (R1 = H, R2 = Et 4a: or Pri 4b; R1 = Me, R2 = Et 4c) and trans-[RuH(NCCMeCO2Et)(PMePh2)4] 5. The molecular structure of 3 shows that the enolato ligand co-ordinates to the ruthenium centre via the cyano group in an octahedral geometry. These hydrido-(enolato)ruthenium(II) complexes catalyse Michael and Knoeevenagel reactions under neutral and mild conditions. The Royal Society of Chemistry 1999.