267403-50-9Relevant academic research and scientific papers
Benzamide derivatives as blockers of Kv1.3 ion channel
Miao, Shouwu,Bao, Jianming,Garcia, Maria L.,Goulet, Joung L.,Hong, Xingfang J.,Kaczorowski, Gregory J.,Kayser, Frank,Koo, Gloria C.,Kotliar, Andrew,Schmalhofer, William A.,Shah, Kashmira,Sinclair, Peter J.,Slaughter, Robert S.,Springer, Marty S.,Staruch, Mary Jo,Tsou, Nancy N.,Wong, Frederick,Parsons, William H.,Rupprecht, Kathleen M.
, p. 1161 - 1164 (2007/10/03)
The voltage-gated potassium channel, Kv1.3, is present in human T-lymphocytes. Blockade of Kv1.3 results in T-cell depolarization, inhibition of T-cell activation, and attenuation of immune responses in vivo. A class of benzamide Kv1.3 channel inhibitors
