267413-07-0

Basic information

• Product Name: 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE
• Synonyms: 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE;1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile,2,3-dihydro-(9CI)
• CAS NO: 267413-07-0
• Molecular Formula: C₈H₇N₃
• Molecular Weight: 145.16
• Product Categories: PYRIDINE
• Mol File: 267413-07-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 303.1°C at 760 mmHg
• Flash Point: 137.1°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 0.00095mmHg at 25°C
• Refractive Index: 1.615
• PKA: 4.16±0.20(Predicted)
• CAS DataBase Reference: 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE(267413-07-0)
• EPA Substance Registry System: 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE(267413-07-0)

Safety Data

• Hazardous Substances Data: 267413-07-0(Hazardous Substances Data)

Usage

General Description

2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile is a chemical compound with the molecular formula C8H6N4. It is a heterocyclic compound that consists of a pyrrolopyridine ring system with a cyano group attached to the fifth carbon. 2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE-5-CARBONITRILE may be used in pharmaceutical research and drug development due to its potential biological activities. It is also known for its potential as a scaffold for designing new drug molecules. The chemical properties and potential applications of 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile make it a topic of interest in medicinal and organic chemistry.

InChI:InChI=1/C9H8N2/c1-2-7-5-8-3-4-10-9(8)11-6-7/h1,5-6H,3-4H2,(H,10,11)

Upstream product

• 115170-40-6 7-aza-5-bromoindoline 
• 10592-27-5 7-azaindoline 
• 557-21-1 zinc(II) cyanide 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 
• 557-21-1 dicyanozinc 

Downstream Products

• 849805-79-4 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid 
• 267876-17-5 N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)-2-(6-methyl-2-oxo-3-phenethylamino-2H-pyrazin-1-yl)-acetamide 
• 556104-19-9 5-aminomethyl-7-azaindoline 

Relevant articles and documents

Histone deacetylase inhibitors and its preparation method and use thereof

The invention discloses a histone deacetylase inhibitor and its preparation method and use, the invention discloses a compound of the formula I as shown, or its crystalline form, or its pharmaceutically acceptable salt, or solvate thereof, or prodrug thereof, or its metabolic product. The invention of the formula I illustrated new compound, has shown good deacetylase inhibition activity, with the histone deacetylase for clinical treatment of diseases associated with abnormal activity of a new pharmaceutical may be.

NOVEL ANTIMALARIA AGENT CONTAINING HETEROCYCLIC COMPOUND

Disclosed is an antimalarial agent containing a compound represented by the formula: [wherein A1 represents a 3-pyridyl group that may have a substituent, a 6-quinolyl group that may have a substituent, or the like; X1 represents a group represented by the formula -C(=O)-NH- or the like; E represents a furyl group, a thienyl group or a phenyl group; with the proviso that A1 may have one to three substituents, and E has one of two substituents] or a salt thereof or hydrates thereof.

Azaindoles: Moderately basic P1 groups for enhancing the selectivity of thrombin inhibitors

Starting from a 2-amino-6-methylpyridine P1 group and following a strategy of enlarging it whilst reducing its polarity, we have developed a series of potent, moderately basic azaindoles which are intrinsically much more selective for thrombin versus tryp