2675-78-7

Upstream product

• 118-52-5 1,3-dichloro-5,5-dimethylhydantoin 
• 24599-58-4 2,5-dimethoxy toluene 
• 172655-08-2 2-[(2-Phenylethoxy)methyl]-5-methyl-1,4-dimethoxybenzene 
• 95-71-6 2-methylbenzene-1,4-diol 
• 5628-37-5 2,5-Bis(methoxymethyl)-1,4-dimethoxybenzene 
• 50874-27-6 1,4-bis(bromomethyl)-2,5-dimethoxybenzene 
• 65109-51-5 2-(Bromomethyl)-5-methyl-1,4-dimethoxybenzene 
• 3948-92-3 bis(2,5-dimethoxy-4-methylphenyl)methane 
• 32176-89-9 1,4-Dimethoxy-2-methoxymethyl-5-methyl-benzene 

Downstream Products

• 124010-13-5 1-(bromomethyl)-4-chloro-2,5-dimethoxybenzene 
• 124010-11-3 Ethyl 4-(acetyloxy)-6-chloro-5,8-dimethoxy-2-naphthalenecarboxylate 
• 124010-10-2 3-Carbethoxy-4-(4-chloro-2,5-dimethoxyphenyl)-3-butenoic acid 
• 90064-48-5 4-chloro-2,5-dimethoxybenzaldehyde 

Relevant academic research and scientific papers

Radical-Cation Catalysis in the Synthesis of Diphenylmethanes via the Dealkylative Coupling of Benzylic Ethers

The dealkylative coupling of benzyl alkyl ethers (ArCH2OR) to yield the corresponding diarylmethanes (ArCH2Ar) together with dialkoxymethane (ROCH2OR) is catalyzed by small amounts of 1-electron oxidants (such as aromatic cation radicals, NO(1+), etc.) or by an equivalent electrochemical (anodic) method.The catalytic method is successfully employed for the facile synthesis of a novel macrocyclic crown ether 18 that contains a diarylmethane linkage.On the basis of the spectral observation of the radical cation ArCH2OR.+ and the excellent catalytic efficiency with turnover numbers in excess of 1E2, an electron-transfer and an alternative electrophilic chain mechanism are discussed for the dealkylative coupling process.

AN EFFICIENT ROUTE TO 3-CHLOROJUGLONES

The novel 4-chloro-2,5-dimethoxybenzaldehyde 1 has been prepared and converted in only three steps to 5-acetoxy-7-carboethoxy-3-chloro-1,4-naphthaquinone 4.Subsequent Diels-Alder reaction affords a tetracyclic enol ether 9 in a regiospecific manner.