50874-27-6

Usage

Uses

Used in Organic Synthesis:
Benzene, 1,4-bis(bromomethyl)-2,5-dimethoxyis used as a reagent in organic synthesis for its ability to facilitate the creation of various chemical compounds. Its reactivity allows for the formation of new bonds and the synthesis of complex molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Benzene, 1,4-bis(bromomethyl)-2,5-dimethoxyis used as a key intermediate in the production of several drugs. Its unique structure and reactivity make it a valuable component in the development of new medications.
Used in Drug Discovery Research:
Benzene, 1,4-bis(bromomethyl)-2,5-dimethoxyis also utilized in research for drug discovery. Its properties and potential interactions with biological systems make it a candidate for the exploration of new therapeutic agents.
Used in Material Development:
Benzene, 1,4-bis(bromomethyl)-2,5-dimethoxyhas potential applications in the development of new materials, where its chemical properties can be leveraged to create innovative products with specific characteristics.

Upstream product

• 150-76-5 4-methoxy-phenol 
• 150-78-7 1,4-dimethoxybezene 
• 3752-97-4 1,4-bis(chloromethyl)-2,5-dimethoxybenzene 
• 52251-27-1 1,4-bis(acetoxymethyl)-2,5-dimethoxybenzene 
• 50-00-0 formaldehyd 
• 13057-17-5 bromethyl methyl ether 
• 51829-43-7 1,4-dihydroxymethyl-2,5-dimethoxybenzaldehyde 

Downstream Products

• 493036-92-3 (E,E)-2,5-bis(2,5-dihexylstyryl)-1,4-dimethoxybenzene 
• 1262213-82-0 2,5-dimethoxy-1,4-dimethylol di-(R)-lactate 
• 52251-27-1 1,4-bis(acetoxymethyl)-2,5-dimethoxybenzene 
• 1262213-83-1 2,5-dimethoxy-1,4-dimethylol di-(S)-mandelate 
• 1379868-76-4 C₄₆H₆₆O₄ 
• 1414652-42-8 C₂₆H₃₈O₆ 
• 5628-37-5 2,5-Bis(methoxymethyl)-1,4-dimethoxybenzene 
• 13949-81-0 2,5-bis(hydroxymethylene)benzene-1,4-diol 
• 51829-43-7 1,4-dihydroxymethyl-2,5-dimethoxybenzaldehyde 
• 13949-75-2 2,5-bis-hydroxymethyl-[1,4]benzoquinone 
• 1333388-13-8 C₃₂H₂₂N₄O₂ 

Relevant academic research and scientific papers

Investigation of two-photon absorption properties in new A-D-A compounds emitting blue and yellow fluorescence

Three new acceptor-donor-acceptor compounds (LBQ, DBQ, BYQ) were synthesized and characterized by infrared, hydrogen nuclear magnetic resonance, mass spectrometry and elemental analysis. Their photophysical properties were investigated including linear ab

Water-soluble red-fluorescent dyes for two-photon deep-tissue imaging

To realize in vivo deep two-photon fluorescence microscopy (TPFM), a probe is required that can undergo two-photon excitation and emit in the optical window of tissues (6501100 nm). In addition, the probe should have high water solubility to avoid harmful

RED FLUORESCENT HIGHLY HYDROSOLUBLE COMPOUND AND FLUORESCENT DYE USING THE SAME

PROBLEM TO BE SOLVED: To provide a hydrosoluble fluorescent probe having property of localizing in a mitochondrion and having light emission in the near infrared. SOLUTION: A fluorescent dye including compound represented by the following formula (1) is u

Rational design, facile synthesis, and linear/nonlinear optical properties of novel two-photon absorption stilbene derivatives with different configurations

Four novel two-photon absorption compounds (1MOBI, 2MOHA, 3BrBI, and 4BrHA), which have assembled stilbene π-bridge, different electron acceptors and donors, were synthesized conveniently via the one-step Horner-Wadsworth-Emmons reaction. Their configurations are A-π-D-π-A, D′-π-D-π-D′, A′-π-A-π-A′, and D-π-A-π-D, respectively. Their linear and nonlinear optical properties including linear absorption, one-photon excited fluorescence, two-photon absorption, and two-photon excited fluorescence, were systematically investigated in various solvents. The results demonstrate that the compounds with dihexylamino donors exhibit good optical properties. 2MOHA and 4BrHA exhibit large two-photon absorption cross-sections (2183 and 1737 GM) in DMF, which are larger than those of many known stilbene derivatives. The relationships between the structures and the optical properties were studied aided with the time-dependent density functional theory calculations.

Refining the model to design α-chymotrypsin superactivators: The role of the binding mode of quaternary ammonium salts

A number of quaternary ammonium salts with bulky hydrophobic moieties are known to provoke the superactivation of α-chymotrypsin (α-CT) in aqueous solution. In particular, benzyl-substituted ammonium and dicationic ammonium-based salts have recently emerged as promising classes of compounds to induce α-CT superactivation and stabilization. Preliminary in silico modelling suggested the α-CT residue tryptophan 215 to be the major anchor point of these additives. In order to achieve a broader knowledge of the enzyme-additive interactions and to validate the modelling studies, new ammonium-based additives were designed and tested. The hydrophobic interaction resulted in being critical to improving superactivation, with [(2,3,5,6-tetramethyl-p-phenylene)dimethylene]bis[triethylammonium bromide] (bisEDuEAB) resulting as the most effective quaternary ammonium superactivating agent studied so far. Finally, a general agreement between in silico outcomes and kinetic parameters was observed, and data interpretation is discussed based on the proposed α-CT/additive binding modes. This journal is

Synthesis, electronic structure, linear and nonlinear photophysical properties of novel asymmetric branched compounds

A series of novel asymmetric branched compounds that utilize a 1,3,5-triazine core and feature D-π-A-(π-D′-π-A′)0-2 configurations (D = donor, A = acceptor, π = conjugated bridge) were designed, successfully synthesized, and fully characterized by 1H NMR, 13C NMR, FT-IR, and HRMS. Their photophysical properties including linear absorption, one-photon excited fluorescence, two-photon absorption, and frequency up-converted fluorescence, were systematically investigated in different solvents. With a rise in the polarity of solvents, the peak positions of the one-photon excited fluorescence are red-shifted and the Stokes shifts increase, while the linear absorption wavelengths change slightly. In addition, the target compounds except CZ show the positive solvatokinetic effect. With a rise in the number of branches, the red shifts of the absorption and emission maxima, the hyperchromicity of the molar absorption coefficients, and the decrease of the Stokes shifts are observed. The peripheral electron donors (carbazole, phenothiazine) and acceptors (pyridine, benzimidazole) also exert an important influence on the photophysical properties. Under excitation of 690–930 nm fs laser pulses, all the target compounds emit frequency up-converted fluorescence with the maximal peaks at 471–575 nm, and the two-photon absorption cross-sections in THF are 132 (PTZ), 182 (CZ), 453 (CZ-Py1), 844 (CZ-Py2), 1244 (CZ-BI1), and 2072 (CZ-BI2) GM, respectively. Their two-photon response is found to be nearly additive with respect to the number of branches. The time-dependent density functional theory calculations were conducted to gain an insight into their electronic structures and to better understand the structure-photophysical property relationships. The results clearly indicate the importance of appropriate structural units on the enhancement of two-photon absorption properties.

Confinement of Br?nsted acidic ionic liquids into covalent organic frameworks as a catalyst for dehydrative formation of isosorbide from sorbitol

The confinement of Br?nsted acidic 1-methyl-3-(3-sulfopropyl)-1H-imidazol-3-ium hydrosulfate ([PSMIm][HSO4]) into the channel walls of two-dimensional (2D) COFs using a one-pot self-assembly strategy was achieved by incorporating an imine-linked TPB-DMTP-COF (TPB, triphenylbenzene; DMTP, dimethoxyterephthaldehyde) as the host. An appropriate loading of [PSMIm][HSO4] is crucial for the BIL-COF hybrids to maintain proper geometry in the channel and sufficient acidic sites for the sorbitol substrate and sorbitan intermediate to enter and react. The best yield of isosorbide (97%) from sorbitol to date was obtained in the presence of BIL-COF-30 as the catalyst under optimized conditions. Besides, BIL-COF-30 can be recycled for at least five runs without activity loss.

XANTHINE DERIVATIVES AND USES THEREOF AS INHIBITORS OF BROMODOMAINS OF BET PROTEINS

The present invention relates to a compound having the following formula (I): (I) wherein: - R is a (C1-C6)alkyl group;- R'' is preferably H;- Ar is a (C5-C12)arylene radical;- X1 is -C(=O)- or -SO2-; and- R' is chosen from the group consisting of possibly substituted (C1-C6)alkyl, heteroaryl, (C5-C12)aryl, and (hetero)cycloalkyl groups, or a pharmaceutically acceptable salt and/or tautomeric form thereof, or its racemates, diastereomers or enantiomers.

Synthesis, photophysical properties, and DNA-binding of novel A-π-D-π-A’ two-photon absorption chromophores

Three novel two-photon absorption chromophores (1BI, 2TAZ, and 3PyB), which have trans-1,4-divinylbenzene π-bridge, methoxy donors, and different acceptors, were synthesized. Their structures were elucidated by means of hydrogen-1 nuclear magnetic resonan

ELECTROCHEMICALLY ACTIVE AGENTS FOR PH MODULATION IN BIOLOGICAL BUFFERS

Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent comprising quinone derivatives that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.