26764-92-1Relevant academic research and scientific papers
Atom- and step-economical preparation of reduced knoevenagel adducts using CO as a deoxygenative agent
Kolesnikov, Pavel N.,Usanov, Dmitry L.,Barablina, Evgeniya A.,Maleev, Victor I.,Chusov, Denis
, p. 5068 - 5071 (2014)
A highly efficient one-step Rh-catalyzed preparation of reduced Knoevenagel adducts of various aldehydes and ketones with active methylene compounds has been developed. The protocol does not require an external hydrogen source and employs carbon monoxide
Reductive Transformations of Carbonyl Compounds Catalyzed by Rhodium Supported on a Carbon Matrix by using Carbon Monoxide as a Deoxygenative Agent
Yagafarov, Niyaz Z.,Usanov, Dmitry L.,Moskovets, Alexey P.,Kagramanov, Nikolai D.,Maleev, Victor I.,Chusov, Denis
, p. 2590 - 2593 (2015/09/15)
An efficient method for the rhodium on carbon matrix catalyzed preparation of secondary and tertiary amines, cyanoesters, and nitriles through the reductive amination/alkylation of carbonyl compounds was developed, including a convenient procedure for the tandem formal reductive addition of acetonitrile to aldehydes. The catalyst could be reused, and at least three consecutive reaction cycles were performed with comparable efficiency. The method was shown to be compatible with functional groups prone to reduction by hydrogen and complex hydrides. Beyond the matrix: An efficient method for the rhodium on carbon matrix catalyzed preparation of secondary and tertiary amines, cyanoesters, and nitriles through the reductive amination/alkylation of carbonyl compounds is developed, including a convenient procedure for the tandem formal reductive addition of acetonitrile to aldehydes. TON=turnover number.
Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR α/γ agonists
Zhang, Hao,Ryono, Denis E.,Devasthale, Pratik,Wang, Wei,O'Malley, Kevin,Farrelly, Dennis,Gu, Liqun,Harrity, Thomas,Cap, Michael,Chu, Cuixia,Locke, Kenneth,Zhang, Litao,Lippy, Jonathan,Kunselman, Lori,Morgan, Nathan,Flynn, Neil,Moore, Lisa,Hosagrahara, Vinayak,Zhang, Lisa,Kadiyala, Pathanjali,Xu, Carrie,Doweyko, Arthur M.,Bell, Aneka,Chang, Chiehying,Muckelbauer, Jodi,Zahler, Robert,Hariharan, Narayanan,Cheng, Peter T.W.
scheme or table, p. 1451 - 1456 (2009/10/15)
The design, synthesis and structure-activity relationships of a novel series of N-phenyl-substituted pyrrole, 1,2-pyrazole and 1,2,3-triazole acid analogs as PPAR ligands are outlined. The triazole acid analogs 3f and 4f were identified as potent dual PPARα/γ agonists both in binding and functional assays in vitro. The 3-oxybenzyl triazole acetic acid analog 3f showed excellent glucose and triglyceride lowering in diabetic db/db mice.
