267651-24-1

Basic information

• Product Name: 1-(3-bromo-2-methoxyphenyl)-2-chloroethanone
• Synonyms: 1-(3-bromo-2-methoxyphenyl)-2-chloroethanone
• CAS NO: 267651-24-1
• Molecular Weight: 263.518
• Mol File: 267651-24-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(3-bromo-2-methoxyphenyl)-2-chloroethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-bromo-2-methoxyphenyl)-2-chloroethanone(267651-24-1)
• EPA Substance Registry System: 1-(3-bromo-2-methoxyphenyl)-2-chloroethanone(267651-24-1)

Safety Data

• Hazardous Substances Data: 267651-24-1(Hazardous Substances Data)

Upstream product

• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 
• 38603-09-7 2,6-dibromoanisole 
• 267651-22-9 1-(3-bromo-2-methoxyphenyl)ethanol 
• 267651-23-0 1-(3-bromo-2-methoxyphenyl)ethan-1-one 

Downstream Products

• 267651-28-5 (S)-3-[3-(3-Bromo-2-methoxy-phenyl)-2-((1S,2R)-2-phenyl-cyclohexyloxycarbonyloxy)-benzofuran-5-yl]-2-(2,2,2-trichloro-ethoxycarbonylamino)-propionic acid methyl ester 
• 267651-27-4 2(S)-(2,2,2-trichloroethoxycarbonylamino)-3-[3-(3-bromo-2-methoxyphenyl)-2-oxo-2,3-dihydrobenzofuran-5-yl]-propionic acid methyl ester 
• 267651-26-3 2(S)-(2,2,2-trichloroethoxycarbonylamino)-3-[3-(3-bromo-2-methoxyphenyl)-benzofuran-5-yl]-propionic acid methyl ester 
• 270588-44-8 2-methoxy-3-(2-oxo-2,3-dihydrobenzofuran-3-yl)-phenylboronic acid 
• 270588-43-7 3-(3-bromo-2-methoxy-phenyl)-3H-benzofuran-2-one 
• 270588-42-6 3-(3-bromo-2-methoxy-phenyl)-benzofuran 
• 270588-41-5 1-(3-bromo-2-methoxy-phenyl)-2-phenoxyethanone 
• 267651-25-2 2(S)-(2,2,2-trichloroethoxycarbonylamino)-3-{4-[2-(3-bromo-2-methoxyphenyl)-2-oxo-ethoxy]-phenyl}-propionic acid methyl ester 

Relevant articles and documents

Method for synthesizing 2 - amino -5 - arylthiazole

The present invention discloses a synthetic method of 2-amino-5-arylthiazole. The method is as below: dropwise adding an organometallic reagent into raw materials of 2,6-dibromo anisole and tetrahydrofuran under nitrogen protection, and stirring at room temperature or low temperature for 2 h until the materials disappear; dropwise adding a tetrahydrofuran solution containing N- methyl-N-methoxy-chloro acetamide and insulating until the disappearance of a TLC indicated intermediate; dropwise adding saturated ammonium chloride solution, separating and extracting the aqueous phase with ethyl acetate; combining the organic phases, and evaporating the solvents to obtain 2'-chloro-3-bromo-2-methoxyacetophenone; adding 2'-chloro-3-bromo-2-methoxyacetophenone, thiourea and ethanol to a reaction flask, and heating at reflux; cooling, adding into an aqueous solution of sodium bicarbonate; and filtering and drying to obtain 2-amino-5-(2'-methoxy-3'-bromo)phenyl-thiazole. The method is easy, realizes one-step synthesis of 2'-chloro-3-bromo-2-methoxyacetophenone intermediate, and utilizes the intermediate for high yield synthesis of 2-amino-5-(3'-bromo-2'-methoxy) phenylthiazole.