267668-46-2

Basic information

• Product Name: [1-(4-chlorophenyl)-2,2-dicyanoethyl]phosphonic acid dimethyl ester
• Synonyms: [1-(4-chlorophenyl)-2,2-dicyanoethyl]phosphonic acid dimethyl ester
• CAS NO: 267668-46-2
• Molecular Weight: 298.666
• Mol File: 267668-46-2.mol

Chemical Properties

• CAS DataBase Reference: [1-(4-chlorophenyl)-2,2-dicyanoethyl]phosphonic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(4-chlorophenyl)-2,2-dicyanoethyl]phosphonic acid dimethyl ester(267668-46-2)
• EPA Substance Registry System: [1-(4-chlorophenyl)-2,2-dicyanoethyl]phosphonic acid dimethyl ester(267668-46-2)

Safety Data

• Hazardous Substances Data: 267668-46-2(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 109-77-3 malononitrile 
• 121-45-9 phosphorous acid trimethyl ester 

Relevant articles and documents

Pyridine-grafted graphene oxide: a reusable acid-base bifunctional catalyst for the one-pot synthesis of β-phosphonomalonates via a cascade Knoevenagel-phospha Michael addition reaction in water

A new acid-base bifunctional catalyst was synthesized by postgrafting of pyridine onto GO. This new catalyst was characterized by different methods such as FT-IR, XRD, TGA, TEM, SEM, EDS, UV-Vis and elemental analysis and employed as a reusable acid-base bifunctional catalyst for the one-pot synthesis of β-phosphonomalonates via a cascade Knoevenagel-phospha Michael addition reaction of aldehydes, malononitrile and dialkyl phosphites in water.

Piperidine and piperazine immobilized on iron oxide nanoparticles as magnetically recyclable heterogeneous catalysts for one-pot synthesis of β-phosphonomalonates

Piperidine and piperazine immobilized on silica-coated γ-Fe 2O3 magnetic nanoparticles were synthesized as new supported bases via the reaction of chloro-functionalized γ-Fe 2O3?SiO2 with piperidine and piperazine, respectively. The resulting bases were employed as magnetically recyclable heterogeneous catalysts for the efficient one-pot three-component synthesis of β-phosphonomalonates. The catalysts were easily separated from the reaction mixture by using a magnet and recycled for five times without significant loss of the catalytic activity. Graphical Abstract: [Figure not available: see fulltext.]

Lanthanum(III) triflate supported on nanomagnetic γ-Fe 2O3: A new magnetically recyclable heterogeneous Lewis acid for the one-pot synthesis of β-phosphonomalonates

Lanthanum(iii) triflate supported on nanomagnetic γ-Fe 2O3 was synthesized and characterized by HRTEM, XRD, ICP, FT-IR, TGA and VSM. It was applied as a magnetically recyclable heterogeneous Lewis acid catalyst for the efficient one-pot synthesis of β- phosphonomalonates via tandem Knoevenagel-phospha-Michael reaction. The catalyst was easily separated from the reaction mixture by magnetic decantation using an external magnet and reused ten times. This journal is the Partner Organisations 2014.

One-pot synthesis of β-phosphonomalonates catalyzed by molecular iodine

A one-pot procedure has been developed for the synthesis of β-phosphonomalonates via P-C bond formation through tandem Knoevenagel-phospha-Michael reaction catalyzed by iodine as a new, inexpensive, nonmetallic, and commercially available catalyst. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]

5-Hydroxypentylammonium acetate as a reusable ionic liquid catalyzes tandem Knoevenagel-phospha-Michael reaction of aldehydes, malononitrile and phosphites

5-Hydroxypentylammonium acetate as a taskspecific ionic liquid promotes efficient tandem Knoevenagel- phospha-Michael reaction of phosphite esters with aryl/heteroaryl/alkyl/salicylaldehydes and malonitrile/ethyl cyanoacetate at room temperature in short

Nano n-propylsulfonated γ-Fe2O3 as magnetically recyclable heterogeneous catalyst for the efficient synthesis of β-phosphonomalonates

Nano n-propylsulfonated γ-Fe2O3 as a new sulfonated nanomagnetic iron oxide was synthesized directly through ring opening reaction of 1,3-propanesultone with nano magnetic γ-Fe2O 3 and used as magnetically recyclable heterogeneous catalyst for the efficient one-pot synthesis of β-phosphonomalonates. The catalyst was easily isolated from the reaction mixture by magnetic decantation using an external magnet and reused at least five times without significant degradation in the activity.

An eco-friendly procedure for one-pot synthesis of β- phosphonomalonates: Micellar solution of sodium stearate catalyzes tandem Knoevenagel-phospha-Michael reaction of aldehydes, malonitrile, and phosphites in aqueous media

A new, one-pot convenient method for the synthesis of a variety of β-phosphonomalonates by a tandem Knoevenagel-phospha-Michael reaction of phosphite esters with aryl/heteroaryl/alkyl aldehydes and malonitrile in an aqueous micellar solution of sodium ste