267884-84-4

Usage

Uses

Used in Pharmaceutical Industry:
CIS-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-BOC-1-NAPHTHALENAMINE is used as a chemical intermediate for the synthesis of Sertraline, which is a widely prescribed antidepressant medication. Its role in the production process is crucial for creating the final drug product that helps in treating various mental health conditions.
Used in Research and Development:
In addition to its application in the pharmaceutical industry, CIS-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-BOC-1-NAPHTHALENAMINE may also be utilized in research and development for the discovery and development of new drugs and therapies. Its unique chemical properties can be explored for potential applications in various areas of medical science.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 87857-41-8 norsertraline 
• 267884-79-7 (4S)-ethyl-4-N,N-(dibenzyl)-4-amino-4-phenyl-(E)-2-butenoate 
• 1446434-14-5 (R_s)-N-[(S)-1,2-dihydronaphthalen-1-yl]-2-methylpropane-2-sulfinamide 
• 1446434-26-9 (S)-tert-butyl (1,2-dihydronaphthalen-1-yl)carbamate 
• 1446434-30-5 (S)-tert-butyl (4-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-1-yl)carbamate 
• 1446469-35-7 (S)-1,2-dihydronaphthalen-1-amine 
• 267884-82-2 (1S,4S)-N,N-(dibenzyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine 
• 267884-77-5 (1S,R,4S)-N,N-(dibenzyl)-4-amino-1-(3,4-dichlorophenyl)-4-phenyl-1-butanol 
• 267884-80-0 (4S)-methyl-N,N-(dibenzyl)-4-amino-4-phenylbutanoate 
• 267884-81-1 (4S)-N,N-(dibenzyl)-4-amino-4-phenyl-1-butanol 
• 193476-02-7 (+)-(2R)-2-[bis(phenylmethyl)amino]-2-phenylethanol 
• 174023-92-8 D-dibenzylaminophenylglycinal 

Downstream Products

• 267884-85-5 cis-(1S,4S)-N-(tert-butoxycarbonyl)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine 
• 79617-96-2 Sertraline 

Relevant academic research and scientific papers

Asymmetric allylation/ring closing metathesis: One-pot synthesis of benzo-fused cyclic homoallylic amines. Application to the formal synthesis of Sertraline derivatives

A one-pot asymmetric allylation/ring closing metathesis (RCM) sequence for the synthesis of cyclic homoallylic amines has been developed. A library of six- and seven-membered benzo-fused products has been synthesized in good yields and complete diastereoselectivity. The new methodology has been applied to the formal syntheses of the antidepressant Sertraline and the epimeric Norsertraline. The methodology is amenable for the synthesis of analogs.

An expedient total synthesis of cis-(+)-sertraline from D-phenylglycine

An efficient and practical total synthesis of cis-(+)-Sertraline is developed involving intramolecular Friedel-Crafts cyclization of an appropriately tailored D-phenylglycine. (C) 2000 Elsevier Science Ltd.