267885-96-1

Basic information

• Product Name: 1-(p-Toluenesulphonyl)-5-benzyl-2-thiohydantoin
• CAS NO: 267885-96-1
• Molecular Weight: 360.458
• Mol File: 267885-96-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(p-Toluenesulphonyl)-5-benzyl-2-thiohydantoin(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(p-Toluenesulphonyl)-5-benzyl-2-thiohydantoin(267885-96-1)
• EPA Substance Registry System: 1-(p-Toluenesulphonyl)-5-benzyl-2-thiohydantoin(267885-96-1)

Safety Data

• Hazardous Substances Data: 267885-96-1(Hazardous Substances Data)

Upstream product

• 13505-32-3 N-tosyl-(S)-phenylalanine 
• 1147550-11-5 ammonium thiocyanate 
• 98-59-9 p-toluenesulfonyl chloride 
• 63-91-2 L-phenylalanine 

Relevant articles and documents

Chiral aryl sulfonyl hydantoins as hypoglycemic agents

Some novel chiral sulfonyl hydantoin derivatives 2a-e and 3a-e have been prepared. p-Toluenesulfonyl chloride on treatment with L-amino acids in presence of K2CO3/H2O yielded N-(p-toluensulfonyl-)amino acids 1a-e which were cyclized in presence of NH4SCN / Ac2O to afford 1-(p-toluenesulfonyl)-5-substituted-2-thiohydantoins 2a-e. These compounds were oxidized with HNO3 to yield 1-(p-toluenesulfonyl)-5-substituted hydantoins 3a-e. The enantiomeric ratios of 3a-e were determined by 1H NMR spectroscopy using Eu(hfc)3. The antidiabetic activity of 3a-d has been determined.