267895-50-1Relevant articles and documents
Synthesis of C2-symmetric guanidino-sugars as potent inhibitors of glycosidases
Le Merrer, Yves,Gauzy, Laurence,Gravier-Pelletier, Christine,Depezay, Jean-Claude
, p. 307 - 320 (2007/10/03)
A series of enantiomerically pure C2-Symmetric guanidino-sugars was synthesized from D-mannitol. The first method described involves direct opening of a bis-epoxide by guanidine, whereas the second one deals with a mercury-catalyzed transformation of a cyclic thiourea into a N,N',N'- trisubstituted guanidine as a key step. The biological activity of these compounds towards several glycosidases has been evaluated. One of them (5) was found to selectively inhibit α-L-fucosidase of bovin kidney (2.8 μM). (C) 2000 Elsevier Science Ltd.
Synthesis of C2-symmetrical cyclic guanidino-sugars from D-mannitol
Gauzy, Laurence,Le Merrer, Yves,Depezay, Jean-Claude
, p. 402 - 404 (2007/10/03)
An efficient method for the synthesis of C2-symmetrical cyclic guanidino-sugars has been developed from 1,2:5,6-dianhydro-3,4-O-methylethylidene-D-mannitol or L-iditol.