268-97-3Relevant academic research and scientific papers
Na2S-mediated synthesis of terminal alkynes from: Gem -dibromoalkenes
Singh, Radhey M.,Nandini, Durgesh,Bharadwaj, Kishor Chandra,Gupta, Tanu,Singh, Raj Pal
, p. 9979 - 9982 (2017)
The Na2S-mediated facile synthesis of terminal alkynes from gem-dibromoalkenes, at 20/40 °C under open flask conditions has been developed. Various precursors derived from heteroaromatic/aromatic/aliphatic aldehydes were found compatible. The reaction is proposed to proceed through the Fritsch-Buttenberg-Wiechell (FBW) rearrangement involving the corresponding vinyl carbene. Using mild reaction conditions with inexpensive Na2S·9H2O under air atmosphere has significant advantages over earlier routes.
