26808-51-5

Basic information

• Product Name: Debilone
• Synonyms: Debilone;(1aR)-1,1,7β,7aβ-Tetramethyl-3β-hydroxy-1aβ,2,3,5,6,7,7a,7bβ-octahydro-1H-cyclopropa[a]naphthalene-5-one;(1aR,7bβ)-1α,1a,2,3,6,7,7a,7b-Octahydro-3β-hydroxy-1,1,7β,7aβ-tetramethyl-5H-cyclopropa[a]naphthalen-5-one;Debilon
• CAS NO: 26808-51-5
• Molecular Formula: C15H22O2
• Molecular Weight: 234.33398
• Mol File: 26808-51-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 135 °C
• Boiling Point: 359.0±21.0 °C(Predicted)
• Appearance: /
• Density: 1.11±0.1 g/cm3(Predicted)
• PKA: 14.20±0.70(Predicted)
• CAS DataBase Reference: Debilone(CAS DataBase Reference)
• NIST Chemistry Reference: Debilone(26808-51-5)
• EPA Substance Registry System: Debilone(26808-51-5)

Safety Data

• Hazardous Substances Data: 26808-51-5(Hazardous Substances Data)

Usage

General Description

Debilone is a synthetic corticosteroid medication that contains the active ingredient prednisolone. It is commonly used to treat a variety of inflammatory and immune-related conditions, including rheumatoid arthritis, asthma, lupus, and ulcerative colitis. Debilone works by reducing inflammation and suppressing the immune system, helping to alleviate symptoms such as pain, swelling, and breathing difficulties. However, it also carries a risk of side effects, especially with long-term use, including increased susceptibility to infections, weight gain, high blood pressure, and osteoporosis. Patients taking Debilone should be closely monitored by a healthcare professional to manage these potential risks.

Upstream product

• 17334-55-3 β-gurjunene 

Relevant articles and documents

Biotransformation of aristolane- and 2,3-secoaromadendrane-type sesquiterpenoids having a 1,1-dimethylcyclopropane ring by Chlorella fusca var. vacuolata, Mucor species, and Aspergillus niger

Biotransformation of the aristolane-type sesquiterpene hydrocarbon (+)-1(10)-aristolene (1) from the crude drug Nardostachys chinensis and of the 2,3-secoaromadendrane-type sesquiterpene lactone plagiochilide (2) from the liverwort Plagiochila fruticosa by three microorganisms, Chlorella fusca var. vacuolata, Mucor species, and Aspergillus niger was investigated. C. fusca var. vacuolata and Mucor sp. introduced oxygen function into the cyclohexane ring of aristolene while A. niger oxidized stereoselectively one methyl of the 1,1-dimethyl group on the cyclopropane ring of aristolanes and 2,3-secoaromadendrane to give C-12 primary alcohol and C-12 carboxylic acid. The possible metabolic pathway of the formation of new metabolites is discussed. The stereostructures of new metabolites were established by a combination of NMR spectroscopy including HMBC and NOESY, X-ray crystallographic analysis, and chemical reaction.