26820-62-2

Basic information

• Product Name: 4-(5-Nitropyridin-2-yl)morpholine
• Synonyms: 4-(5-NITRO-2-PYRIDINYL)MORPHOLINE;4-(5-NITRO-2-PYRIDYL)MORPHOLINE;4-(5-NITROPYRIDIN-2-YL)MORPHOLINE;4-(5-nitro-2-pyridyl)-morpholin;2-Morpholino-5-nitropyridine;4-(5-Nitro-pyridin-2-yl)morpholine, 90+%;2-(4-Morpholinyl)-5-nitropyridine, 95%;6-(4-Morpholin-1-yl)-3-nitropyridine
• CAS NO: 26820-62-2
• Molecular Formula: C₉H₁₁N₃O₃
• Molecular Weight: 209.2
• Product Categories: nitro-compound
• Mol File: 26820-62-2.mol
• Article Data: 49

Chemical Properties

• Melting Point: 112-114°C
• Boiling Point: 406.4 °C at 760 mmHg
• Flash Point: 199.6 °C
• Appearance: /
• Density: 1.325 g/cm³
• Vapor Pressure: 8.16E-07mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 1.52±0.10(Predicted)
• CAS DataBase Reference: 4-(5-Nitropyridin-2-yl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-Nitropyridin-2-yl)morpholine(26820-62-2)
• EPA Substance Registry System: 4-(5-Nitropyridin-2-yl)morpholine(26820-62-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-26-36/37/39
• RTECS: QE7450000
• HazardClass: IRRITANT
• Hazardous Substances Data: 26820-62-2(Hazardous Substances Data)

Usage

General Description

"4-(5-Nitropyridin-2-yl)morpholine is a chemical compound belonging to the class of organic compounds known as morpholines, which contain a six-membered ring with one nitrogen atom, one oxygen atom and four carbon atoms. The particular structure of 4-(5-Nitropyridin-2-yl)morpholine includes a nitropyridine group attached to the morpholine ring, which may contribute to its reactivity and potential applications. Like all chemicals, this compound must be handled with appropriate safety measures due to potential risks or toxicity. Currently, there may not be extensive research or widespread use of this specific compound, suggesting it might be primarily of interest in experimental or specialized settings.

InChI:InChI=1/C9H11N3O3/c13-12(14)8-1-2-9(10-7-8)11-3-5-15-6-4-11/h1-2,7H,3-6H2

Upstream product

• 110-91-8 morpholine 
• 456-24-6 2-Fluoro-5-nitropyridine 
• 904326-93-8 [6-(morpholin-4-yl)pyridin-3-yl]boronic acid 
• 4548-45-2 2-chloro-5-nitropyridine 
• 1346257-87-1 1-(5-nitro-2-pyridyloxy)pyridin-2(1H)-one 
• 1346257-86-0 (5-nitro-2-pyridyloxyimino)-2-pyridylacetonitrile 
• 1346257-85-9 (5-nitro-2-pyridyloxyimino)malononitrile 
• 1346257-84-8 ethyl cyano(5-nitro-2-pyridyloxyimino)acetate 
• 1346257-83-7 diethyl (5-nitro-2-pyridyloxyimino)malonate 
• 4487-59-6 2-bromo-5-nitropyridine 
• 2530-26-9 3-nitropyridine 
• 110-89-4 piperidine 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 14212-87-4 1,1-bis(N-morpholinyl)ethylene 

Downstream Products

• 1201916-40-6 (6-amino-5-((2,6-dichIoro-3-fluorophenyl)ethoxy)pyridazin-3-yI)-N-(6-(morpholin-4-yl)pyridin-3-yl)carboxamide 

Relevant articles and documents

A sensitive method for the determination of gold and palladium based on dispersive liquid-liquid microextraction combined with flame atomic absorption spectrometric determination using: N -(6-morpholin-4-ylpyridin-3-yl)- N ′-phenylthiourea

A new method for the determination of gold and palladium was developed by dispersive liquid-liquid microextraction separation-preconcentration and flame atomic absorption spectrometry detection. In the proposed approach, N-(6-morpholin-4-ylpyridin-3-yl)-N′-phenylthiourea (MPPT) was synthesized as a complexing agent. The complexation ability of the MPPT was explored by examining the effect of a series of heavy metal ions, including Mn2+, Pd2+, Ni2+, Cd2+, Co2+, Cu2+, Au3+, Pb2+, Zn2+ and Fe3+, using the DLLME procedure. The MPPT exhibited pronounced selectivity toward Pd2+ and Au3+ ions at different pH levels. Factors influencing the extraction efficiency and complex formation were examined, i.e. the pH of the sample solution, the concentration of the chelating agent, the extraction and dispersive solvent type and volume, the sample volume, and foreign ions, etc. Optimal conditions for quantitative recoveries were pH 5.5 for gold and pH 1.5 for palladium, 125 μL of % 0.4 MPPT, 1200 μL of methanol and 125 μL of carbon tetrachloride. The presented method showed a good linearity within a range of 30-230 and 25-200 μg L-1 with the detection limits of 1.75 and 1.65 μg L-1 for Au and Pd, respectively. The relative standard deviation (RSD) was below 2.8% at 50 μg L-1 for both ions (n = 10). The developed method was simple, fast, cost efficient, and sensitive for the extraction and preconcentration of gold and palladium in samples of liquids (sea, stream water) and solids (stream sediment, ores, and electronic waste).

FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF

The present disclosure relates to a class of fused pyrimidine compounds of Formula I, their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates, and hydrates thereof. The present disclosure also relates to a process of preparation of these fused pyrimidine compounds, and to pharmaceutical compositions containing them.

MALT1 INHIBITORS AND USES THEREOF

The invention provides compounds of formula (I) wherein R1, R2, R3, R4 and R5 are as defined in the specification which are potent inhibitors of the enzyme MALT1 and are useful in the treatment of autoimmune disorders and diseases and as an immunooncology approach to the treatment of cancer, especially bladder cancer, colon cancer, hepatocellular cancer and small cell or non-small cell lung cancer.