26831-07-2

Basic information

• Product Name: 1-ethyl-4-phenylquinazolin-2(1H)-one
• CAS NO: 26831-07-2
• Molecular Weight: 250.3
• Mol File: 26831-07-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-ethyl-4-phenylquinazolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ethyl-4-phenylquinazolin-2(1H)-one(26831-07-2)
• EPA Substance Registry System: 1-ethyl-4-phenylquinazolin-2(1H)-one(26831-07-2)

Safety Data

• Hazardous Substances Data: 26831-07-2(Hazardous Substances Data)

Upstream product

• 100-61-8 N-methylaniline 
• 107125-70-2 lithium N-phenyl-N-methylcarbamate 

Downstream Products

• 128487-81-0 1-Ethyl-4-phenyl-4-(tetrahydro-furan-2-yl)-3,4-dihydro-1H-quinazolin-2-one 
• 70724-06-0 1-ethyl-4-phenyl-3,4-dihydroquinazolin-2(1H)-one 
• 128487-79-6 1-Ethyl-4-phenyl-4-(9H-xanthen-9-yl)-3,4-dihydro-1H-quinazolin-2-one 

Relevant articles and documents

Carbon Dioxide: A Reagent for the Simultaneous Protection of Nucleophilic Centres and the Activation of Alternative Locations to Electrophilic Attack. Prt III. A New Synthetic Method for the ortho-Substitution of N-Monoalkylanilines

N-Methyl- and N-ethyl-aniline are regiospecifically converted into a range of ortho-substituted derivatives, using carbon dioxide both for N-protection and as an intermediate carbanion stabilizing group, and t-butyllithium to lithiate the ortho-carbon atom.The rersulting lithium N-(ortho-substituted-phenyl)-N-methyl- and -N-ethylcarbamates undergo smooth acid-catalysed decarboxylation under mild conditions.No alpha-substituted products were detected.