26840-48-2

Basic information

• Product Name: 1-(2-MORPHOLIN-4-YLETHYL)-1H-BENZIMIDAZOL-2-AMINE
• Synonyms: ART-CHEM-BB B000443;AKOS B000443;1-(2-MORPHOLIN-4-YLETHYL)-1H-BENZIMIDAZOL-2-AMINE;1-(2-Morpholin-4-ylethyl)-1H-benzoimidazol-2-amine;1-(2-Morpholin-4-yl-ethyl)-1H-benzoimidazol-2-ylamine;[1-(2-morpholinoethyl)benzimidazol-2-yl]amine;1-(2-morpholin-4-ylethyl)benzimidazol-2-amine;1-(2-morpholinoethyl)-2-benzimidazolamine
• CAS NO: 26840-48-2
• Molecular Formula: C₁₃H₁₈N₄O
• Molecular Weight: 246.31
• Mol File: 26840-48-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-MORPHOLIN-4-YLETHYL)-1H-BENZIMIDAZOL-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-MORPHOLIN-4-YLETHYL)-1H-BENZIMIDAZOL-2-AMINE(26840-48-2)
• EPA Substance Registry System: 1-(2-MORPHOLIN-4-YLETHYL)-1H-BENZIMIDAZOL-2-AMINE(26840-48-2)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 26840-48-2(Hazardous Substances Data)

Usage

Description

1-(2-MORPHOLIN-4-YLETHYL)-1H-BENZIMIDAZOL-2-AMINE is a complex chemical compound featuring a benzimidazole ring and a morpholine ring connected by an ethyl chain. It is a potent inhibitor of poly(ADP-ribose) polymerases (PARPs), enzymes that play a role in DNA repair and programmed cell death.

Uses

Used in Pharmaceutical Industry:
1-(2-MORPHOLIN-4-YLETHYL)-1H-BENZIMIDAZOL-2-AMINE is used as an inhibitor for PARPs to increase the sensitivity of cancer cells to treatments such as chemotherapy and radiation therapy. Its inhibition of these enzymes can be beneficial in cancer therapy, potentially leading to new therapeutic options for various types of cancer.
Used in Treatment of Inflammatory Conditions:
1-(2-MORPHOLIN-4-YLETHYL)-1H-BENZIMIDAZOL-2-AMINE is used as an anti-inflammatory agent due to its ability to modulate the immune response, which may help in treating inflammatory conditions.
Used in Neurodegenerative Disease Treatment:
1-(2-MORPHOLIN-4-YLETHYL)-1H-BENZIMIDAZOL-2-AMINE is used as a neuroprotective agent for its potential to protect against neuronal damage, making it a candidate for treating neurodegenerative conditions.

Upstream product

• 3240-94-6 N-(2-chlorethyl)morpholine 
• 934-32-7 1H-benzimidazol-2-amine 
• 3647-69-6 4-(2-chloroethyl)morpholine hydrochride 
• 78156-04-4 N-[2-(morpholin-4-yl)ethyl]-1,2-phenylenediamine 
• 506-68-3 bromocyane 
• 40828-54-4 1H-benzimidazole-2-sulfonic acid 
• 945481-57-2 C₁₃H₁₇N₃O₄S 
• 5322-94-1 1-(2-morpholinoethyl)-1H-benzo[d]imidazole 

Downstream Products

• 509093-57-6 3-methanesulfonyl-N-(1-(2-morpholin-4-yl-ethyl)-1H-benzoimidazol-2-yl)-benzamide 

Relevant articles and documents

Synthesis and pharmacological activity of 2-(biphenyl-4-yl)imidazo[1,2-a]benzimidazoles

An efficient method for the synthesis of novel 9H-imidazo[1,2-a]benzimidazole derivatives containing a biphenyl substituent at position 2 was developed. These compounds, belonging to the privileged substructures, have been tested for a wide range of pharmacological activities in the in vitro test panel. It was shown that the synthesized derivatives demonstrated high antioxidant activity, some of them inhibit type 1B protein tyrosine phosphatase, activate AMP-activated protein kinase, possess antiplatelet properties, and a rare and very interesting kind of activity, the ability to break cross-links of glycated proteins. The most active compounds can be suggested for further optimization.

Synthesis and some conversions of N-substituted benzimidazole-2-sulfonic acids

A series of N-substituted benzimidazole-2-sulfonic acids was synthesized in good yield by the N-alkylation of benzimidazole-2-sulfonic acids by alkylation with simple and functionalized alkylating agents under mild conditions. The corresponding N-substitu