40828-54-4

Basic information

• Product Name: 1H-BENZIMIDAZOLE-2-SULFONIC ACID
• Synonyms: 1H-BENZIMIDAZOLE-2-SULFONIC ACID;1H-BENZOIMIDAZOLE-2-SULFONIC ACID;AKOS BBS-00000680;BENZIMIDAZOLE-2-SULFONIC ACID;IFLAB-BB F0347-0827;1H-BENZIMIDAZOLE-2-SULFONIC ACID 98%;H-BENZIMIDAZOLE-2-SULFONIC ACID;1H-Benzimidazole-2-sulfonicacid(9CI)
• CAS NO: 40828-54-4
• Molecular Formula: C₇H₆N₂O₃S
• Molecular Weight: 198.2
• Product Categories: BENZIMIDAZOLE;Imidazoles & Benzimidazoles;Benzimidazoles;Building Blocks;Heterocyclic Building Blocks
• Mol File: 40828-54-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 116-119 °C(lit.)
• Appearance: white to light beige crystalline powder
• Density: 1.4876 (rough estimate)
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: 2-8°C
• PKA: -1.47±0.40(Predicted)
• CAS DataBase Reference: 1H-BENZIMIDAZOLE-2-SULFONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-BENZIMIDAZOLE-2-SULFONIC ACID(40828-54-4)
• EPA Substance Registry System: 1H-BENZIMIDAZOLE-2-SULFONIC ACID(40828-54-4)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 40828-54-4(Hazardous Substances Data)

Usage

Chemical Properties

white to light beige crystalline powder

Uses

Benzimidazole 2-Sulfonic Acid is a versatile reactant used in the preparation of bis(benzimidazol-2-yl)amines with antitrichinellosis activity.

General Description

1H-Benzimidazole-2-sulfonic acid (BISA) is a glutamate racemase (GR) inhibitor. It is a promising candidate for developing antibacterial drugs. BISA can be prepared by the oxidation of 1H-benzimidazole-2-thiol using hydrogen peroxide in the presence of potassium hydroxide.

InChI:InChI=1/C7H6N2O3S/c10-13(11,12)7-8-5-3-1-2-4-6(5)9-7/h1-4H,(H,8,9)(H,10,11,12)

Upstream product

• 583-39-1 2,3-dihydrobenzimidazol-2-thione 
• 74376-23-1 2-phenyl-4H-benzo[4,5]imidazo[2,1-b][1,3]thiazin-4-one 
• 326007-50-5 2-phenyl-2,3-dihydro-4H- [1,3]thiazino[3,2-a]benzimidazol-4-one 
• 120341-04-0 1-aminobenzimidazole-2-sulfonic acid 

Downstream Products

• 934-32-7 1H-benzimidazol-2-amine 
• 615-16-7 1,3-dihydro-2H-benzimidazol-2-one 
• 15108-18-6 2-hydrazinobenzimidazole 
• 2851-12-9 2-(piperidin-1-yl)-1H-benzo[d]imidazole 
• 621-72-7 2-benzylbenzimidazole 
• 90331-19-4 1-ethyl-1H-benzimidazole-2-sulfonic acid 
• 55548-66-8 3-phenyl-1,4-dihydro-1,2,4-triazino[4,3-a]benzimidazole 
• 23085-25-8 2-phenyl-1⁽⁹⁾-imidazo[1,2-a]benzimidazole 
• 30534-59-9 2-(4-chlorophenyl)-1⁽⁹⁾-imidazo[1,2-a]benzimidazole 
• 1616251-35-4 2-(4-fluorophenyl)-1⁽⁹⁾-imidazo[1,2-a]benzimidazole 
• 36289-17-5 1,2-diphenylimidazo<1,2-a>benzimidazole 
• 1616251-36-5 2-(4-methylphenyl)-1-phenylimidazo[1,2-a]benzimidazole 
• 126936-31-0 1-[2-(piperidin-1-yl)ethyl]-2-phenylimidazo-[1,2-a]benzimidazole 
• 174312-26-6 2-{2-(4-methylphenyl)-1H-imidazo[1,2-a]benzimidazol-1-yl}ethanol 

Relevant articles and documents

Some chemical properties of 2,3-dihydro-4H-[1,3]thiazino[3,2-a] benzimidazol-4-one and 2-aryl-2,3-dihydro-4H-[1,3]thiazino[3,2-a]benzimidazol-4- ones

We have studied the reaction of 2,3-dihydro-4H-[1,3]thiazino[3,2-a] benzimidazol-4-one and 2-aryl-2,3-dihydro-4H-[1,3]thiazino[3,2-a]benzimidazol-4- ones with amines, alkylating reagents, and hydrogen peroxide. We have shown that the presence of an aryl substituent at the 2 position of [1,3-thiazino[3,2-a] benzimidazol-4-ones has a substantial effect on the direction of the reactions. 2006 Springer Science+Business Media, Inc.

Synthesis of derivatives of 1-amino-benzimidazoline-2-thione

A new method for producing 1-aminobenzimidazoline-2-thione by the reaction of 1-amino-2-chloro-benzimidazole or 1-aminobenzimidazole-2-sulfonic acid with sodium hydrosulfide is proposed. The pathways of synthesis of N-acylamino-2-methylthiobenzimidazoles

Novel Desulphurization of Thiourea Derivatives by Alkaline Autoxidation

Autoxidation of 1,3-disubstituted thioureas in the presence of oxygen and tertiary butoxide in tertiary butanol afforded the corresponding ureas in good yields together with small amounts of the corresponding guanidines while the same treatment of benz- or naphth-imidazole-2-thiones gave the parent imidazoles and the 2-sulphonic acids.