268544-18-9Relevant academic research and scientific papers
A chemical approach to illustrate the principle of signal transduction cascades using the avidin-biotin system
Morpurgo, Margherita,Hofstetter, Heike,Bayer, Edward A.,Wilchek, Meir
, p. 12734 - 12739 (1998)
A new approach to illustrate the principle of signal transduction and to assemble protein multilayers is described. It is based on competing affinities of two different ligands for the same binding site of a protein. A low-affinity ligand can be attached
Azobenzene derivatives as labeling agents and intermediates thereof
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, (2008/06/13)
A compound of the formula I: wherein R is H or —N═N-2-carboxyphenyl; A is (CH2)nor —CH═CH—, wherein n is an integer from 0 to 10, or A may also be —CH(COOH)— when R is —N═N-2-carboxyphenyl; and X is a radical selected from the group consisting of: (i) Cl; (ii) COOR1, wherein R1is p-nitrophenyl or N-succinimidyl; (iii) CONH—NHR2, wherein R2is H, COO(t-butyl) or COObenzyl; (iv) CONH—[B]—NHR3, wherein R3is H, COOR1, or CO—[B′]—maleimido, wherein R1is t-butyl, p-nitrophenyl or N-succinimidyl, and B and B′, the same or different, are (CH2)nwherein n is an integer from 2 to 10; (v) CONH—[B]—COOR4, wherein R4is H, C1-C8alkyl, N-succinimidyl; (vi) CONH—[B]—OH; (vii) CONH—[B]—CONH—NHR2, wherein R2is H, COO(t-butyl) or COObenzyl; and (viii) NHR2, wherein R2is H, COO(t-butyl) or COObenzyl, when A is —CH(COOH)— and R is —N═N-2-carboxyphenyl. The 4′-hydroxyazobenzene-2-carboxylic acid (HABA) compounds are novel reagents for labeling, isolation and detection of biological molecules.
