2687-52-7Relevant academic research and scientific papers
Direct sequential C-H iodination/organoyl-thiolation for the benzenoid A-ring modification of quinonoid deactivated systems: A new protocol for potent trypanocidal quinones
Jardim, Guilherme A. M.,Oliveira, Willian X. C.,De Freitas, Rossimiriam P.,Menna-Barreto, Rubem F. S.,Silva, Thaissa L.,Goulart, Marilia O. F.,Da Silva Júnior, Eufranio N.
, p. 1686 - 1691 (2018)
We report a sequential C-H iodination/organoyl-thiolation of naphthoquinones and their relevant trypanocidal activity. Under a combination of AgSR with a copper source, sulfur-substituted benzenoid quinones were prepared in high yields (generally >90%). This provides an efficient and general method for preparing A-ring modified naphthoquinoidal systems, recognized as a challenge in quinone chemistry.
