268729-67-5Relevant academic research and scientific papers
Synthesis and antiviral evaluation of 1-O-hexadecylpropanediol-3-P- acyclovir: Efficacy against HSV-1 infection in mice
Beadle, James R.,Kini, Ganesh D.,Aldern, Kathy A.,Gardner, Michael F.,Wright, Kristine N.,Rybak, Rachel J.,Kern, Earl R.,Hosteller, Karl Y.
, p. 471 - 479 (2000)
We synthesized, 1-O-hexadecylpropanediol-3-P-acyclovir, an orally bioavailable lipid prodrug of acyclovir and evaluated it for in vitro and in vivo activity against herpes simplex virus infections. Although 1-O- hexadecylpropanediol-3-P-acyclovir was less
