Synthesis and antiviral evaluation of 1-O-hexadecylpropanediol-3-P- acyclovir: Efficacy against HSV-1 infection in mice

Article abstract of DOI:10.1080/15257770008033022

We synthesized, 1-O-hexadecylpropanediol-3-P-acyclovir, an orally bioavailable lipid prodrug of acyclovir and evaluated it for in vitro and in vivo activity against herpes simplex virus infections. Although 1-O- hexadecylpropanediol-3-P-acyclovir was less

Full text of DOI:10.1080/15257770008033022

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Nucleosides, Nucleotides and Nucleic
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Synthesis and Antiviral Evaluation of 1-
O-Hexadecylpropanediol-3-P-acyclovir:
Efficacy Against HSV-1 Infection in Mice
James R. Beadle a b , Ganesh D. Kini a b , Kathy A. Aldern a b
,
Michael F. Gardner a b , Kristine N. Wright a b , Rachel J. Rybak b c
Earl R. Kern b c & Karl Y. Hostetler a b
,
a Department of Medicine , University of California , San Diego,
305 Clinical Sciences Building, 9500 Gilman Drive, La Jolla, CA,
92093-0676
b the VA Medical Center , San Diego, CA, 92161
c Department of Pediatrics , The University of Alabama at
Birmingham , 309 Bevill Biomedical Research Building, 845 19th St.
South, Birmingham, AL, 35294-2170
Published online: 24 Sep 2006.
To cite this article: James R. Beadle , Ganesh D. Kini , Kathy A. Aldern , Michael F. Gardner , Kristine
N. Wright , Rachel J. Rybak , Earl R. Kern & Karl Y. Hostetler (2000) Synthesis and Antiviral Evaluation
of 1-O-Hexadecylpropanediol-3-P-acyclovir: Efficacy Against HSV-1 Infection in Mice, Nucleosides,
Nucleotides and Nucleic Acids, 19:1-2, 471-479, DOI: 10.1080/15257770008033022
To link to this article: http://dx.doi.org/10.1080/15257770008033022
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