268737-24-2Relevant academic research and scientific papers
A novel dealkylation affording 3-aminoimidazo[1,2-a]pyridines: Access to new substitution patterns by solid-phase synthesis
Blackburn, Christopher,Guan, Bing
, p. 1495 - 1500 (2000)
The three-component synthesis of 3-aminoimidazo[1,2-a]pyridine derivatives has been extended by a novel acid-induced dealkylation reaction that removes the 1,1,3,3-tetramethylbutyl group derived from the isonitrile input. This reaction was conducted on the solid-phase using the HMBA linker and the resulting products subjected to reductive alkylation using several aldehydes, thereby accessing novel substitution patterns at the 3-position. (C) 2000 Elsevier Science Ltd.
