268740-71-2Relevant academic research and scientific papers
Synthesis of oligodeoxyribonucleotide bearing 2'-S-alkyl residue and its effect on the duplex stability
Ozaki, Hiroaki,Sato, Yuichi,Azuma, Sadaji,Sawai, Hiroaki
, p. 593 - 601 (2000)
2'-Deoxy-2'-S-hexyluridine derivative was synthesized from 2,2'- anhydrouridine and 1-hexanethiol and incorporated into an oligodeoxyribonucleotide. The thermal stability of the duplexes formed by the 2'-S-hexyl modified ODN with either the complementary DNA or RNA strand was decreased compared to the unmodified counterparts.
