Synthesis of oligodeoxyribonucleotide bearing 2'-S-alkyl residue and its effect on the duplex stability

Article abstract of DOI:10.1080/15257770008035010

2'-Deoxy-2'-S-hexyluridine derivative was synthesized from 2,2'- anhydrouridine and 1-hexanethiol and incorporated into an oligodeoxyribonucleotide. The thermal stability of the duplexes formed by the 2'-S-hexyl modified ODN with either the complementary DNA or RNA strand was decreased compared to the unmodified counterparts.

Full text of DOI:10.1080/15257770008035010

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Nucleosides, Nucleotides and Nucleic
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Synthesis of Oligodeoxyribonucleotide
Bearing 2′-S-Alkyl Residue and its Effect
on the Duplex Stability
Hiroaki Ozaki a , Yuichi Sato a , Sadaji Azuma a & Hiroaki Sawai a
a Department of Chemistry, Faculty of Engineering , Gunma
University , 1-5-1 Tenjin-cho, Kiryu, Gunma, 376-8515, Japan
Published online: 24 Sep 2006.
To cite this article: Hiroaki Ozaki , Yuichi Sato , Sadaji Azuma & Hiroaki Sawai (2000) Synthesis
of Oligodeoxyribonucleotide Bearing 2′-S-Alkyl Residue and its Effect on the Duplex Stability,
Nucleosides, Nucleotides and Nucleic Acids, 19:3, 593-601, DOI: 10.1080/15257770008035010
To link to this article: http://dx.doi.org/10.1080/15257770008035010
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