268741-98-6

Upstream product

• 100-39-0 benzyl bromide 
• 71400-63-0 N-tert-butyloxycarbonyl-3-iodo-L-tyrosine 
• 34619-03-9 tert-butyldicarbonate 
• 70-78-0 3-Iodo-L-tyrosine 
• 845786-31-4 N-t-Boc-O-t-butyldiphenylsilylethyl-3-iodo-(L)-tyrosine benzyl ester 

Downstream Products

• 292836-01-2 Ethyl 5-{(2S)-3-(Benzyloxy)-2-[(tert-butoxycarbonyl)amino]-3-oxopropyl}-2-hydroxybenzoate 
• 292836-02-3 Ethyl 5-{(2S)-3-(Benzyloxy)-2-[(tert-butoxycarbonyl)amino]-3-oxopropyl}-2-(2-ethoxy-2-oxoethoxy)benzoate 
• 1159060-10-2 C₂₂H₂₆INO₅ 
• 1192262-08-0 (S)-benzyl 2-(tert-butoxycarbonylamino)-3-(3-iodo-4-(methoxymethoxy)phenyl)propanoate 
• 702685-76-5 C₃₃H₄₄N₂O₁₂ 
• 623563-66-6 5-(2-tert-butoxycarbonylamino-2-carboxy-ethyl)-2-ethoxycarbonylmethoxy-benzoic acid ethyl ester 
• 845786-31-4 N-t-Boc-O-t-butyldiphenylsilylethyl-3-iodo-(L)-tyrosine benzyl ester 

Relevant academic research and scientific papers

tert-buyldiphenylsilylethyl ("TBDPSE"): A practical protecting group for phenols

(Chemical Equation Presented) A new protection group for phenols, the 2-(tert-butyldiphenylsilyl)ethyl (TBDPSE) group, has been prepared and investigated. Protection of a variety of substituted phenols proceeds in good to excellent yield. The group is stable to mild acid, base, hydrogenolysis conditions, and lithium/ halogen exchange on the protected phenol. Removal is achieved with strong acid or standard fluoride treatment.

Thieme Chemistry Journal awardees - Where are they now? Scope of tyrosine O-arylations with boronic acids: Optimized synthesis of an orthogonally protected isodityrosine

The Evans-Chan-Lam variant of the Ullman condensation has been explored to deliver O-arylated tyrosines and tyrosinyl peptides. Key modifications for success were the slow addition of boronic acids to the phenol-catalyst mixture. Selectivity and scope are investigated. Georg Thieme Verlag Stuttgart.

Synthesis of a cyclic pentapeptide mimic of the active site His-Tyr cofactor of cytochrome c oxidase

(Chemical Equation Presented) Arylboronic acid based technology provides a mild, regioselective, and nontoxic N-arylation procedure for accessing the unusual N-arylated side chain histidine found in the active site of cytochrome c oxidase (CcO). The N-ary

Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors

A salicylate second site binder was linked to three classes of phosphotyrosine mimetics to produce potent protein tyrosine phosphatase 1B (PTP1B) inhibitors which exhibit significant selectivity against other phosphatases including the most homologous mem

Inhibitors of protein tyrosine phosphatase

The present invention comprises small molecular weight, non-peptidic inhibitors of formulae I-VII of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).

Preparation of phosphatase inhibitors

Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, R1, R2, R3, R4 and R5 are as defined in the specification. Such compounds are tyrosine phosphatase inhibitors and useful in the treatment or prevention of Type II Diabetes Mellitus. Also encompassed by the invention are formulations comprising the noted compounds, processes for preparing such compounds, a method for treating or preventing Type II Diabetes Mellitus.