19832-78-1

Basic information

• Product Name: 2-Propen-1-one, 1-(4-methylphenyl)-
• Synonyms: 4-methylphenyl vinyl ketone
• CAS NO: 19832-78-1
• Molecular Formula: C10H10O
• Molecular Weight: 146.189
• Mol File: 19832-78-1.mol
• Article Data: 52

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-(4-methylphenyl)-(19832-78-1)
• EPA Substance Registry System: 2-Propen-1-one, 1-(4-methylphenyl)-(19832-78-1)

Safety Data

• Hazardous Substances Data: 19832-78-1(Hazardous Substances Data)

Usage

Uses

Used as a reagent in the asymmetric synthesis of tetrahydropyranoindoles and tetrahydro-β-carbonlies.

Upstream product

• 33994-09-1 β-bromoethyl-p-tolyl ketone 
• 814-68-6 acryloyl chloride 
• 108-88-3 toluene 
• 91306-50-2 α-phenylselenenyl-4'-methylpropiophenone 
• 76644-52-5 rac-3-acetoxycyclohexene 
• 76973-15-4 1-(4-methyl)phenyl-3-(1-imidazolyl)-2-propen-1-one 
• 87015-45-0 1-(p-tolyl)-3-tosylpropan-1-one 
• 58824-48-9 1-(4-methylphenyl)-2-propen-1-ol 
• 1826-67-1 vinyl magnesium bromide 
• 104-87-0 4-methyl-benzaldehyde 
• 2564-83-2 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical 
• 40122-37-0 1-(p-tolyl)cyclopropan-1-ol 
• 67-64-1 acetone 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 959-07-9 1-Phenyl-3-(p-tolyl)pyrazolin 
• 87015-45-0 1-(p-tolyl)-3-tosylpropan-1-one 
• 93390-44-4 5-(p-tolyl)-5-oxopentanoic acid methyl ester 
• 138174-24-0 1-(p-tolyl)hex-5-en-1-one 
• 130749-67-6 (E)-3-(2,4-Dimethoxy-pyrimidin-5-yl)-1-p-tolyl-propenone 
• 106696-59-7 1-phenyl-6-(p-tolyl)hexane-1,6-dione 
• 1023272-19-6 (2,2-difluorocyclopropyl)(4-methylphenyl)methanone 
• 1061305-12-1 (2S)-2-(4-methylphenyl)-2,3,4,6,7,8-hexahydroquinolin-5(1H)-one 
• 1190719-56-2 2-(9-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-4-yl)-1-p-tolylethanone 
• 1218988-57-8 (R)-2-oxo-1-(3-oxo-3-(p-tolyl)propyl)cyclopentane-1-carbonitrile 
• 1255940-66-9 [InCl(CH₃C₆H₄COCH₂CH₂)2] 
• 13145-56-7 1,4-bis(4-tolyl)butane-1,4-dione 
• 1256285-04-7 2-(6-fluoro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone 
• 1256285-00-3 2-(7,9-dimethyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone 

Relevant articles and documents

Dimethyl Sulfoxide Serves as a Dual Synthon: Construction of 5-Methyl Pyrimidine Derivatives via Four Component Oxidative Annulation

An efficient potassium persulfate mediated four component reaction for the construction of 5-methyl pyrimidine derivatives has been established from readily available methyl ketones, amidine hydrochlorides and dimethyl sulfoxide. This transformation featu

Design and synthesis of Mannich base-type derivatives containing imidazole and benzimidazole as lead compounds for drug discovery in Chagas Disease

The protozoan parasite Trypanosoma cruzi is the causative agent of Chagas disease, the most important parasitic infection in Latin America. The only treatments currently available are nitro-derivative drugs that are characterised by high toxicity and limited efficacy. Therefore, there is an urgent need for more effective, less toxic therapeutic agents. We have previously identified the potential for Mannich base derivatives as novel inhibitors of this parasite. To further explore this family of compounds, we synthesised a panel of 69 new analogues, based on multi-parametric structure-activity relationships, which allowed optimization of both anti-parasitic activity, physicochemical parameters and ADME properties. Additionally, we optimized our in vitro screening approaches against all three developmental forms of the parasite, allowing us to discard the least effective and trypanostatic derivatives at an early stage. We ultimately identified derivative 3c, which demonstrated excellent trypanocidal properties, and a synergistic mode of action against trypomastigotes in combination with the reference drug benznidazole. Both its druggability and low-cost production make this derivative a promising candidate for the preclinical, in vivo assays of the Chagas disease drug-discovery pipeline.

A silver-catalyzed radical ring-opening reaction of cyclopropanols with sulfonyl oxime ethers

A silver-catalyzed ring-opening reaction of cyclopropanols with sulfonyl oxime ethers has been developed. The protocol was conducted under mild reaction conditions to provide a series of ?-keto oxime ethers with moderate to good yields. The reaction proceeded in a stereoselective manner for CF3-containing oxime ethers to provide a single stereoisomer, while an inseparableEandZmixture was obtained for CN-containing oxime ethers. Mechanistic studies indicate that the reaction proceededviaa radical mechanism.