26892-90-0

Basic information

• Product Name: 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: ETHYL 4-HYDROXYQUINOLINE-3-CARBOXYLATE;4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER, 95+%;4-keto-1H-quinoline-3-carboxylic acid ethyl ester;ethyl 4-oxo-1H-quinoline-3-carboxylate;3-Quinolinecarboxylic acid, 4-hydroxy-, ethyl ester;3-Ethoxycarbonyl-4-quinolinol
• CAS NO: 26892-90-0
• Molecular Formula: C₁₂H₁₁NO₃
• Molecular Weight: 217.22
• EINECS: -0
• Product Categories: Acids and Derivatives;Heterocycles
• Mol File: 26892-90-0.mol
• Article Data: 45

Chemical Properties

• Melting Point: 271°C(lit.)
• Boiling Point: 343.7 °C at 760 mmHg
• Flash Point: 161.7 °C
• Appearance: /
• Density: 1.246 g/cm³
• Vapor Pressure: 6.92E-05mmHg at 25°C
• Refractive Index: 1.569
• PKA: 2.62±0.50(Predicted)
• CAS DataBase Reference: 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER(26892-90-0)
• EPA Substance Registry System: 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER(26892-90-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 26892-90-0(Hazardous Substances Data)

Usage

General Description

4-Hydroxyquinoline-3-carboxylic acid ethyl ester is a chemical compound with a molecular formula of C12H11NO3. It is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceuticals. 4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER possesses antimicrobial properties and has been studied for its potential use as an antibacterial and antifungal agent. Additionally, it has also been investigated for its potential anti-inflammatory and antioxidant properties. 4-Hydroxyquinoline-3-carboxylic acid ethyl ester is a versatile chemical with potential applications in various fields, including medicine and material science.

InChI:InChI=1/C12H11NO3/c1-2-16-12(15)9-7-13-10-6-4-3-5-8(10)11(9)14/h3-7H,2H2,1H3,(H,13,14)

Upstream product

• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 54535-22-7 diethyl (anilinomethylene)malonate 
• 497-19-8 sodium carbonate 
• 62-53-3 aniline 
• 40516-46-9 diethyl (ethoxymethylene)malonate 
• 52119-39-8 ethyl (2-nitrobenzoyl)acetate 
• 552-16-9 ortho-nitrobenzoic acid 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 408508-16-7 (2-formylamino-phenyl)-propiolic acid ethyl ester 
• 116659-85-9 ethyl 3-(2-aminophenyl)-2-propynoate 
• 360795-67-1 ethyl 2-isocyanobenzoate 
• 87-25-2 2-ethoxycarbonylaniline 
• 72368-50-4 ethyl 2-(formylamino) benzoate 
• 13720-94-0 ethyl 4-chloroquinoline-3-carboxylate 

Downstream Products

• 18471-99-3 1,4-dihydro-1-methyl-4-oxoquinoline-3-carboxylic acid 
• 34785-11-0 4-hydroxy-3-quinoline carboxylic acid 
• 13720-94-0 ethyl 4-chloroquinoline-3-carboxylate 
• 915722-80-4 (R)-4-[4-(3-methylpiperazin-1-yl)phenylamino]quinoline-3-carboxylic acid ethyl ester 
• 923585-74-4 4-[4-(3,3,4-trimethylpiperazin-1-yl)phenylamino]quinoline-3-carboxylic acid ethyl ester 
• 923585-75-5 (R)-4-[4-(3,4-dimethylpiperazin-1-yl)phenylamino]quinoline-3-carboxylic acid ethyl ester 
• 77779-36-3 2-(4-chlorophenyl)-pyrazolo[4,3-c]quinolin-3-one 
• 77779-60-3 2-phenyl-pyrazolo[4,3-c]quinolin-3(5H)-one 
• 77779-50-1 2-(p-methoxyphenyl)-pyrazolo[4,3-c]quinolin-3(5H)-one 
• 1027028-91-6 4-[N'-(2-Chloro-phenyl)-hydrazino]-quinoline-3-carboxylic acid ethyl ester 
• 13721-01-2 4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 873050-34-1 N-(5-amino-2-propoxyphenyl)-4-oxo-1H-quinoline-3-carboxamide 
• 116289-25-9 4-((2-hydroxyethyl)amino)quinoline 

Relevant articles and documents

Syntheses and photochromic behavior of biquinolinium salts

Three isomers of N,N′-dibenzy-biquinolinium dibromide were synthesized and their photoinduced coloration properties were investigated in the thin poly(N-vinylpyrrolidone) films. Upon photo-irradiation, the colorless film of 4,4′-biquinolinium salt became

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Synthesis method and device of 4 -hydroxyquinoline -3 - formic acid

The invention relates to the technical field of medicine preparation, and particularly discloses a synthesis method and device of 4 -hydroxyquinoline -3 - formic acid, wherein o-nitrobenzoic acid and a monoethyl propionate potassium salt are condensed to obtain 3 - (2 - nitrophenyl) -3 - oxopropanoate. The ethyl powder is reacted with 3 - (2 - nitrophenyl) -3 - oxopropanoate to obtain 3 - (2 - aminophenyl) -3 - oxopropanoate. 3 - (2 - Aminophenyl) -3 - oxopropanoate was reacted with DMF-DMA and DMF via a closed loop to give 4 -hydroxyquinoline -3 - ethyl ester. The 4 -hydroxyquinoline -3 - formate was hydrolyzed under basic conditions to give 4 -hydroxyquinoline -3 - formic acid. 4 -hydroxyquinoline -3 - formic acid has the advantages of low cost, short reaction time and simple post-treatment in the synthesis process.

METHODS OF TREATMENT FOR CYSTIC FIBROSIS

This application describes methods of treating cystic fibrosis comprising administering Compound I:, a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising any of the foregoing.