26893-22-1

Basic information

• Product Name: 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylic acid
• Synonyms: 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylic acid;3-Quinolinecarboxylic acid,4-hydroxy-6,7-dimethoxy-
• CAS NO: 26893-22-1
• Molecular Formula: C₁₂H₁₁NO₅
• Molecular Weight: 249.221
• Mol File: 26893-22-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylic acid(26893-22-1)
• EPA Substance Registry System: 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylic acid(26893-22-1)

Safety Data

• Hazardous Substances Data: 26893-22-1(Hazardous Substances Data)

Usage

General Description

4-hydroxy-6,7-dimethoxyquinoline-3-carboxylic acid is a chemical compound that belongs to the quinoline carboxylic acid class. It is a derivative of quinoline and contains a carboxylic acid functional group. 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylic acid has been studied for its potential pharmaceutical applications, including its antioxidant and anti-inflammatory properties. It is also known for its ability to chelate metal ions, making it of interest in various industrial and environmental applications. Additionally, 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylic acid has been investigated for its potential role in the treatment of various diseases, including cancer and neurodegenerative disorders, due to its ability to inhibit certain enzymes and pathways involved in disease progression.

Upstream product

• 6315-89-5 3,4-dimethoxyaniline 
• 251986-55-7 4,5-dimethoxycarbonyl-1-(3',4'-dimethoxyphenyl)-1H-pyrrole-2,3-dione 
• 251986-61-5 6,7-dimethoxy-4-oxo-1,4-dihydro-quinoline-2,3-dicarboxylic acid dimethyl ester 
• 251986-67-1 6,7-dimethoxy-4-oxo-1,4-dihydro-quinoline-2,3-dicarboxylic acid 3-methyl ester 
• 251986-48-8 methyl 3-carbomethoxy-3-(3',4'-dimethoxyphenyl)amino-2-propenoate 
• 26717-39-5 [[(3,4-Dimethoxyphenyl)amino]methylene]malonic acid,diethyl ester 
• 13436-14-1 ethyl 6,7-dimethoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylate 
• 13436-14-1 ethyl 4-hydroxy-6,7-dimethoxyquinoline-3-carboxylate 

Downstream Products

• 35654-56-9 6,7-dimethoxy-4-chloroquinoline 
• 358680-92-9 6,7-dimethoxy-4-[2-(1-phenylhydrazino)]quinoline 
• 190727-05-0 N-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl}-(4-nitrophenyl)carboxamide 
• 190726-66-0 Ki₆₉₄₅ 

Relevant articles and documents

Identification of potent and selective inhibitors of PDGF receptor autophosphorylation

We report the structure-activity relationship of quinoline and quinazoline derivatives, which include urea, thiourea, urethane, and acylthiourea groups, as inhibitors of the platelet-derived growth factor (PDGF) receptor autophosphorylation. Our previous studies showed that the quinoline and quinazoline derivatives including urea, thiourea, and carbamate groups were highly potent compounds as the PDGF receptor autophosphorylation inhibitor, but these compounds did not exhibit receptor selectivity between the PDGF receptor and the c-kit receptor. As a result of further synthesis and biological evaluation, we have found that the quinoline and quinazoline-acylthiourea derivatives showed not only good inhibitory activity for the PDGF receptor but also receptor selectivity between the PDGF receptor and the c-kit receptor. Furthermore N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(2- methylbenzoyl)thiourea exhibited potent oral efficacy in in vivo assay using the rat carotid balloon injury model. Therefore, the quinoline and quinazoline-acylthiourea derivatives may be expected to have potential as therapeutic agents for the treatment of restenosis.

Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them

Heterocyclylalkylpiperidine derivatives of general formula (I) in their enantiomeric or diastereoisomeric forms or mixtures of these forms, and/or, where appropriate, in their syn or anti form or a mixture thereof, as well as any salt thereof.

A synthesis of 4-quinolone-3-carboxylic acids via pyrolysis of N- aryldioxopyrrolines

A synthesis of 4-quinolone-3-carboxylic acids (8) was achieved by pyrolysis of 4,5-dimethoxycarbonyl-1-aryl-1H-pyrrole-2,3-diones (3) followed by selective demethoxycarbonylation of the resulting 2,3-dimethoxycarbonyl-4- quinolones (4) in excellent overall yields.