127285-54-5

Basic information

• Product Name: 6,7-Dimethoxy-3H-quinolin-4-one
• Synonyms: 6,7-Dimethoxy-1,4-dihydro-4-quinolinone;6,7-Dimethoxyquinolin-4(1H)
• CAS NO: 127285-54-5
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.212
• Mol File: 127285-54-5.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 396.537°C at 760 mmHg
• Flash Point: 204.776°C
• Appearance: /
• Density: 1.206
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.78±0.50(Predicted)
• CAS DataBase Reference: 6,7-Dimethoxy-3H-quinolin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-Dimethoxy-3H-quinolin-4-one(127285-54-5)
• EPA Substance Registry System: 6,7-Dimethoxy-3H-quinolin-4-one(127285-54-5)

Safety Data

• Hazardous Substances Data: 127285-54-5(Hazardous Substances Data)

Usage

General Description

6,7-Dimethoxy-3H-quinolin-4-one is a chemical compound that belongs to the class of organic compounds known as quinolinones. These are compounds containing a quinoline moiety bearing a ketone group at the ring carbon atom. Quinoline is a heterocyclic aromatic organic compound with the chemical formula C9H7N. This specific compound, 6,7-Dimethoxy-3H-quinolin-4-one, contains two methoxy functional groups attached to its structure, making it a dimethyl ether derivative of quinolinone. It has not been extensively studied, and its properties and potential applications are still largely unknown.

InChI:InChI=1/C11H11NO3/c1-14-10-5-7-8(6-11(10)15-2)12-4-3-9(7)13/h4-6H,3H2,1-2H3

Upstream product

• 4101-30-8 2-amino-4,5-dimethoxyacetophenone 
• 109-94-4 formic acid ethyl ester 
• 4101-32-0 4',5'-dimethoxy-2'-nitroacetophenone 
• 26893-22-1 1,4-Dihydro-6,7-dimethoxy-4-oxo-3-quinolinecarboxylic acid 
• 213699-53-7 5-(((3,4-dimethoxyphenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 127172-22-9 (E)-3-(N,N-dimethylamino)-1-(3,4-dimethoxyphenyl)-2-propen-1-one 
• 26717-39-5 [[(3,4-Dimethoxyphenyl)amino]methylene]malonic acid,diethyl ester 
• 6315-89-5 3,4-dimethoxyaniline 
• 13436-14-1 ethyl 6,7-dimethoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylate 

Downstream Products

• 347151-53-5 4-(6,7-Dimethoxyquinolin-4-yloxy)phenylcarbamic acid phenyl ester 
• 190728-25-7 4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline 
• 127285-64-7 6,7-dimethoxy-1-(4-methoxybenzyl)-4(1H)-quinolone 
• 849217-68-1 cabozantinib 
• 516526-44-6 4-(2-fluoro-4-nitro-phenoxy)-6,7-dimethoxy-quinoline 
• 426843-15-4 3-chloro-6,7-dimethoxy-4-quinolone 
• 358680-92-9 6,7-dimethoxy-4-[2-(1-phenylhydrazino)]quinoline 

Relevant articles and documents

Novel substituted pyrazolo [1, 5-a] pyrimidine compound and preparation method and application thereof

The invention provides a novel substituted pyrazolo [1, 5-a]pyrimidine compound and a preparation method and application thereof, and particularly relates to a pyrazolo [1, 5-a]pyrimidine-containing quinoline derivative shown as a general formula (I) and pharmaceutically acceptable salts thereof, and substituent groups X, Ar and A have meanings given in the specification. The invention also relates to a compound represented by the general formula (I), wherein the compound has a strong c-Met kinase inhibition effect. The invention also relates to application of the compound and the pharmaceutically acceptable salt thereof in preparation of drugs for treating and/or preventing diseases caused by abnormal high expression of c-Met kinase, especially application in preparation of drugs for treating and/or preventing cancers.

Co(III)-Catalyzed Enaminone-Directed C-H Amidation for Quinolone Synthesis

We report herein the development of a Co(III)-catalyzed enaminone-directed C-H amidation method for synthetic access to quinolones, an important heterocyclic scaffold for diverse pharmaceutically active structures. The C-H coupling with dioxazolones and subsequent deacylation of an installed amide group allow consecutive C-N coupling generation of quinolones with wide-ranging compatible substituent patterns.

INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY

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