269064-07-5Relevant academic research and scientific papers
Serotonin transport inhibitors
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, (2008/06/13)
The present invention relates to the therapeutic use of non-amine tropane analogues that bind to the SERT to treat neuropsychiatric disorders.
2-carbomethoxy-3-aryl-8-bicyclo[3.2.1]octanes: Potent non-nitrogen inhibitors of monoamine transporters
Meltzer,Blundell,Yong,Chen,George,Gonzalez,Madras
, p. 2982 - 2991 (2007/10/03)
Cocaine is a potent central nervous system stimulant with severe addiction liability. Its reinforcing and stimulant properties derive from inhibition of monoamine transport systems, in particular the dopamine transporter (DAT). This inhibition results in
3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes inhibit WIN 35,428 binding potently and selectively at the dopamine transporter
Meltzer, Peter C.,Blundell, Paul,Huang, Hong,Liu, Shanghao,Yong, Yaw F.,Madras, Bertha K.
, p. 581 - 590 (2007/10/03)
The search for medications for cocaine abuse has focused upon the design of potential cocaine antagonists or cocaine substitutes which interact at the dopamine transporter of mammalian systems. This manuscript describes the synthesis and biological evalua
