14252-05-2Relevant articles and documents
Chenier,Kao
, p. 3730,3733 (1976)
Bicyclo[3.2.1]octanes: Synthesis and inhibition of binding at the dopamine and serotonin transporters
Meltzer, Peter C.,Blundell, Paul,Chen, Zhengming,Yong, Yaw F.,Madras, Bertha K.
, p. 857 - 862 (1999)
Herein we report the synthesis of a series of bicyclo[3.2.1]octanes and their binding characteristics at the dopamine and serotonin transporters. The data confirm that a heteroatom at position 8 of the tropane nucleus is not a prerequisite for binding since the bicyclo[3.2.1]octanes prove potent inhibitors of both transporters. Therefore the three-dimensional topology of the ligand may be more important than specific functionality with respect to stereospecific binding at the acceptor site.
Volpi,Pietra
, p. 4867 (1972)
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Kropp,P.J.
, p. 5783 - 5791 (1969)
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McKinney,Patel
, p. 4059,4060,4062 (1973)
COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS
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Page/Page column 147, (2008/06/13)
Compounds represented by formula (I) : or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, Y1, and Z are as defined herein, are useful for treating flavivi?dae viral infections Said viral infection is Hepatitis C virus (HCV), bovme viral diarrhea virus (BVDV), hog cholera virus, dengue fever virus, Japanese encephalitis virus or yellow fever virus
Ring expansions of 2-haloethynyl-2-norbornanols
Djuardi, Elsa,Bovonsombat, Pakorn,Mc Nelis, Edward
, p. 11793 - 11802 (2007/10/02)
2-Haloethynyl-2-norbornanols react with iodine and Koser's reagent in acetonitrile to afford two ring-expanded products, 2-[(Z)-haloiodomethylidene]bicyclo[3.2.1]octan-3-one and 3-[(Z)-haloiodomethylidene]bicyclo[3.2.1]octan-2-one. These results contrast with the 2-haloethynyl-2-bornanols which lead to the corresponding 3-octanones.