269070-78-2Relevant articles and documents
Scaffold hopping with molecular field points: Identification of a cholecystokinin-2 (CCK2) receptor pharmacophore and its use in the design of a prototypical series of pyrrole- and imidazole-based CCK2 antagonists
Low, Caroline M. R.,Buck, Ildiko M.,Cooke, Tracey,Cushnir, Julia R.,Kalindjian, S. Barret,Kotecha, Atul,Pether, Michael J.,Shankley, Nigel P.,Vinter,Wright, Laurence
, p. 6790 - 6802 (2007/10/03)
A new molecular modeling approach has been used to derive a pharmacophore of the potent and selective cholecystokinin-2 (CCK2) receptor antagonist 5 (JB93182), based on features shared with two related series. The technique uses "field points"
Gastrin and cholecystokinin receptor ligands
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, (2008/06/13)
Compounds of formula (I) and their pharmaceutically acceptable salts are ligands at gastrin and/or cholecystokinin receptors. X and Y are independently ═N—, —N(R5)—═CH—, —S— or —O—. n is from 1 to 4; R1is H or C1to C1