269072-16-4Relevant articles and documents
Imidazo[1,2-a]pyridine derivatives, methods of preparing the same and use thereof
-
Paragraph 0155-0156, (2017/10/31)
The present invention relates to an imidazo[1,2-a]pyridine derivative, and more specifically, to an imidazo[1,2-a]pyridine derivative having excellent gastric acid secretion inhibitory activity, a method of preparing the same, and a use thereof. The imidazo[1,2-a]pyridine derivative according to the present invention has gastric acid secretion inhibitory activity, and can be usefully applied for preventing or treating gastrointestinal inflammatory diseases or gastric-related diseases.(AA) Control group(BB) Example 6(CC) Example 7(DD) Embodiment 11COPYRIGHT KIPO 2017
Optionally substituted pyrido[2,3-d]pyridine-2,4(1H,3H)-diones and pyrido[2,]pyrimidine-2(1H,3H)-ones
-
, (2011/03/17)
The present invention relates to optionally substituted pyrido[2,3-d]pyrimidine-2,4(1H,3H)-diones or optionally substituted pyrido[2,3-d]pyrimidine-2(1H,3H)-ones, i.e., compounds of Formula I: STR1 wherein: Y is --CH2 -- or --C(O)--; R1 is hydrogen or --(CH2)n --R7, wherein: R7 is aryl or heteroaryl, and n is 1 or 2, provided that when Y is --C(O)--, R7 is heteroaryl; and R2, R3, R4, R5 and R6 are hydrogen, or one is selected from lower alkyl, halo, carboxy, methoxycarbonyl, carbamoyl, methylcarbamoyl, di-methylcarbamoyl, methylcarbonyl, methylthio, methylsulfinyl, methylsulfonyl, hydroxymethyl, amino, trifluoromethyl, cyano or nitro; or R2, R3, R4 and R5 are independently selected from hydrogen, lower alkyl, nitro, chloro, fluoro, methoxycarbonyl or methylcarbonyl, provided at least one is hydrogen, and R6 is hydrogen; or a pharmaceutically acceptable ester, ether or salt thereof.