269078-81-1

Basic information

• Product Name: (R,S)-Fmoc-3-amino-3-(2-naphthyl)-propionic acid
• Synonyms: (R,S)-Fmoc-3-amino-3-(naphthalen-2-yl)-propionic acid;FMoc-3-AMino-3-(2-naphthyl)propionic acid
• CAS NO: 269078-81-1
• Molecular Formula: C28H23NO4
• Molecular Weight: 437.49
• Mol File: 269078-81-1.mol

Chemical Properties

• Boiling Point: 687.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.294±0.06 g/cm3(Predicted)
• Storage Temp.: Store at?0-5°C
• Solubility: DMF (Sparingly), DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 4.19±0.10(Predicted)
• CAS DataBase Reference: (R,S)-Fmoc-3-amino-3-(2-naphthyl)-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R,S)-Fmoc-3-amino-3-(2-naphthyl)-propionic acid(269078-81-1)
• EPA Substance Registry System: (R,S)-Fmoc-3-amino-3-(2-naphthyl)-propionic acid(269078-81-1)

Safety Data

• Hazardous Substances Data: 269078-81-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
(R,S)-Fmoc-3-amino-3-(2-naphthyl)-propionic acid is used as a building block for the synthesis of complex organic molecules, leveraging its unique structural features to create novel compounds with potential applications in various chemical processes.
Used in Peptide Synthesis:
In the field of peptide synthesis, (R,S)-Fmoc-3-amino-3-(2-naphthyl)-propionic acid is used as a protected amino acid for the stepwise assembly of peptides. The Fmoc group allows for the selective deprotection and coupling of this amino acid with others, facilitating the controlled synthesis of peptide sequences.
Used in Peptide Conformation Studies:
(R,S)-Fmoc-3-amino-3-(2-naphthyl)-propionic acid is utilized as a component in peptides to study their conformation due to the steric and aromatic effects introduced by the 2-naphthyl group. This aids researchers in understanding the structure and dynamics of peptides, which is crucial for drug design and understanding protein functions.
Used in Peptide-Protein Interaction Research:
(R,S)-Fmoc-3-amino-3-(2-naphthyl)-propionic acid is used as a tool in research to investigate the interactions between peptides and proteins. The presence of the 2-naphthyl group can influence how peptides bind to or interact with target proteins, providing insights into molecular recognition and binding mechanisms.
Used in the Creation of Peptide Libraries:
(R,S)-Fmoc-3-amino-3-(2-naphthyl)-propionic acid is used as a key component in the generation of peptide libraries, which are collections of peptides with varying sequences. These libraries are essential for high-throughput screening and the discovery of bioactive peptides with potential therapeutic or diagnostic applications.

Upstream product

• 66-99-9 β-naphthaldehyde 
• 84418-43-9 9-fluorenylmethyl carbamate 

Relevant articles and documents

Catalytic asymmetric three-component synthesis of homoallylic amines

It takes three to make things go right: The first direct asymmetric three-component reaction of aldehydes, carbamates, and allyltrimethylsilane leading to enantioenriched homoallylic amines has been developed using a new chiral disulfonimide catalyst (see scheme). The method employs readily available, inexpensive, and nontoxic starting materials and is applicable to both aromatic and aliphatic aldehydes. Copyright