26910-41-8

Usage

Uses

Used in Pharmaceutical Synthesis:
[(2-chloropropan-2-yl)sulfinyl]benzene is used as an intermediate in the pharmaceutical industry for the development of new drugs. Its unique chemical structure allows for the creation of a wide range of therapeutic compounds, making it a valuable asset in drug discovery and design.
Used in Agrochemical Production:
In the agrochemical industry, [(2-chloropropan-2-yl)sulfinyl]benzene is utilized as a key component in the synthesis of various pesticides and other agricultural chemicals. Its incorporation into these products helps improve their effectiveness in protecting crops and controlling pests.
Used as a Building Block in Organic Chemistry:
[(2-chloropropan-2-yl)sulfinyl]benzene serves as a versatile building block in organic chemistry, enabling the synthesis of a diverse array of organic compounds. Its reactivity and structural features make it an attractive candidate for use in the development of novel materials and chemical products.
Safety Precautions:
Given the potential hazards associated with [(2-chloropropan-2-yl)sulfinyl]benzene, it is crucial to handle this chemical with care and follow proper safety protocols. This includes using appropriate personal protective equipment, ensuring proper ventilation, and adhering to established guidelines for storage and disposal.

Upstream product

• 4170-69-8 isopropyl phenyl sulfoxide 
• 3019-20-3 isopropylthiobenzene 
• 7205-94-9 chloromethyl phenyl sulfoxide 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Synthesis and allergenic potential of a 15-hydroperoxyabietic acid-like model: Trapping of radical intermediates

To better understand the skin sensitization mechanism of 15-hydroperoxyabietic acid-like compounds, 2-(1'-hydroperoxy-1'-methylethyl)-4a-methyl-3,4,4a,5,6,7-hexahydronaphthalene 7 was synthesized. The allergenic activity of this compound was tested on mice using the local lymph node assay, and further evaluated on guinea pigs using the Freund's complete adjuvant test. Using these methods, hydroperoxide 7 was found to be a strong sensitizer. Radical-trapping experiments were carried out on this compound in the presence of the spin-trapping agent, 1,1,3,3-tetramethylisoindolin-2-yloxyl 17, using light to induce radicals. The formation of carbon-centered radicals derived from compound 7 by intramolecular cyclization of an oxygen-centered radical was observed. The reaction of these intermediates with 17 gave various adducts in a very low yield, but a 1/1 mixture of diastereomers 18a and 18b (0.1% yield) was isolated and characterized, together with compound 19 (0.03% yield). The results suggest that carbon-centered reactive radicals are formed from allylic hydroperoxides and that this could be the possible mechanism involved in allergic contact dermatitis to abietic acid.

Solid-Phase Silica-Gel Catalyzed α-Halogenation of Alkyl Aryl Sulfoxides with N-Halosuccinimides

Alkyl aryl sulfoxides are readily halogenated by silica-gel supported N-halosuccinimides.The conversion of optically active alkyl 4-methylphenyl sulfoxides into 1-haloalkyl 4-methylphenyl sulfoxides is accompanied by inversion of configuration at the S-atom.The stereoselectivity of the solid-phase halogenation of alkyl aryl sulfoxides is much higher than that observrd for the halogenation in solution.